GSM6881331

Dataset: gse221521 • Sample: Control group RNA456 • Status: Healthy control
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Quality Control Metrics

12,204,548 Total counts Group median: 12,762,148 • 34.5%ile (≈ Median)
25,565 Detected genes Group median: 2,606 • 19.9%ile (↓ Low)
7 Mitochondrial fraction (%) Group median: 6 • 63.0%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

44.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.02
bar=donor   line=cohort median 		0.17 11.1%
FOXO3 Insulin/IGF-1 Signaling 16.81
bar=donor   line=cohort median 		12.92 77.5%
CETP Lipid Metabolism 0.35
bar=donor   line=cohort median 		0.40 38.1%
SIRT6 Sirtuin Family 3.75
bar=donor   line=cohort median 		3.67 54.2%
SIRT1 Sirtuin Family 3.48
bar=donor   line=cohort median 		3.48 51.6%
SIRT3 Sirtuin Family 0.89
bar=donor   line=cohort median 		1.10 17.4%
IGF1R Insulin/IGF-1 Signaling 7.88
bar=donor   line=cohort median 		4.33 94.6%
KLOTHO Anti-aging 0.12
bar=donor   line=cohort median 		0.06 81.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 41.2%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 60.43
bar=donor   line=cohort median 		35.28 82.1%
TP53 Tumor Suppression 2.26
bar=donor   line=cohort median 		3.83 4.4%
SHC1 Signal Transduction 8.04
bar=donor   line=cohort median 		8.77 24.1%
ACE Signal Transduction 0.23
bar=donor   line=cohort median 		0.39 20.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 12,928.7 90,413
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,551.2 181,729
3 MT-CO1 ENSG00000198804 protein_coding 7,903.9 148,746
4 MT-CO3 ENSG00000198938 protein_coding 6,034.5 57,740
5 MT-CO2 ENSG00000198712 protein_coding 5,667.6 47,313
6 MT-RNR1 ENSG00000211459 Mt_rRNA 5,254.3 61,177
7 MT-ND1 ENSG00000198888 protein_coding 4,810.3 56,124
8 FTL ENSG00000087086 protein_coding 4,728.8 50,268
9 MT-ND4 ENSG00000198886 protein_coding 4,489.2 75,499
10 MT-ND3 ENSG00000198840 protein_coding 4,151.3 17,530

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,996.6
bar=donor   line=cohort median 		1,535.8 1,385.4 75.4%
2 S100A9 protein_coding 12,928.7
bar=donor   line=cohort median 		10,851.3 9,235.1 75.9%
3 IL1B protein_coding 8.1
bar=donor   line=cohort median 		5.6 6.1 67.6%
4 CXCL8 protein_coding 295.7
bar=donor   line=cohort median 		220.4 207.4 65.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.7
bar=donor   line=cohort median 		1.7 2.4 35.5%
6 FCGR3B protein_coding 176.2
bar=donor   line=cohort median 		145.0 129.3 67.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,250.1
bar=donor   line=cohort median 		709.1 706.2 85.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 37.5
bar=donor   line=cohort median 		66.1 56.4 18.4%
9 CD3E protein_coding 26.5
bar=donor   line=cohort median 		37.6 37.7 16.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.2
bar=donor   line=cohort median 		3.1 3.1 23.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 120.4
bar=donor   line=cohort median 		302.3 281.6 6.0%
12 GNLY protein_coding 63.4
bar=donor   line=cohort median 		80.1 70.7 39.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 245.0
bar=donor   line=cohort median 		598.7 582.1 19.9%
14 HBA1 protein_coding 593.5
bar=donor   line=cohort median 		2,133.6 1,960.7 9.6%
15 HBA2 protein_coding 284.7
bar=donor   line=cohort median 		1,142.2 1,083.5 8.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,903.9
bar=donor   line=cohort median 		6,862.1 6,938.4 64.0%
17 MT-CO2 protein_coding 5,667.6
bar=donor   line=cohort median 		6,023.6 5,810.8 45.3%
18 MT-ND1 protein_coding 4,810.3
bar=donor   line=cohort median 		3,656.3 3,718.2 78.0%
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