GSM6881332

Dataset: gse221521 • Sample: DM group RNA457 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

17,372,714 Total counts Group median: 12,709,871 • 96.1%ile (↑ High)
28,056 Detected genes Group median: 2,638 • 89.9%ile (↑ High)
3 Mitochondrial fraction (%) Group median: 6 • 4.4%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

43.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.06
bar=donor   line=cohort median 		0.17 17.9%
FOXO3 Insulin/IGF-1 Signaling 19.01
bar=donor   line=cohort median 		12.92 92.0%
CETP Lipid Metabolism 0.64
bar=donor   line=cohort median 		0.40 85.8%
SIRT6 Sirtuin Family 3.42
bar=donor   line=cohort median 		3.67 35.5%
SIRT1 Sirtuin Family 2.69
bar=donor   line=cohort median 		3.48 15.3%
SIRT3 Sirtuin Family 0.73
bar=donor   line=cohort median 		1.10 7.0%
IGF1R Insulin/IGF-1 Signaling 0.91
bar=donor   line=cohort median 		4.33 9.1%
KLOTHO Anti-aging 0.14
bar=donor   line=cohort median 		0.06 85.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.21
bar=donor   line=cohort median 		0.07 88.3%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 76.12
bar=donor   line=cohort median 		35.28 92.0%
TP53 Tumor Suppression 1.55
bar=donor   line=cohort median 		3.83 1.3%
SHC1 Signal Transduction 8.06
bar=donor   line=cohort median 		8.77 24.6%
ACE Signal Transduction 0.28
bar=donor   line=cohort median 		0.39 32.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 21,270.4 211,738
2 MT-RNR2 ENSG00000210082 Mt_rRNA 6,444.6 174,546
3 FTL ENSG00000087086 protein_coding 5,808.6 87,894
4 HBA1 ENSG00000206172 protein_coding 4,304.4 128,620
5 MT-CO1 ENSG00000198804 protein_coding 4,276.6 114,565
6 S100A8 ENSG00000143546 protein_coding 3,714.5 80,341
7 MT-CO2 ENSG00000198712 protein_coding 3,538.4 42,046
8 MT-RNR1 ENSG00000211459 Mt_rRNA 3,248.3 53,836
9 TMSB10 ENSG00000034510 protein_coding 3,003.3 24,053
10 MT-CO3 ENSG00000198938 protein_coding 2,437.1 33,194

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 3,714.5
bar=donor   line=cohort median 		1,568.6 1,385.4 97.7%
2 S100A9 protein_coding 21,270.4
bar=donor   line=cohort median 		10,144.6 9,235.1 94.0%
3 IL1B protein_coding 3.5
bar=donor   line=cohort median 		6.9 6.1 22.5%
4 CXCL8 protein_coding 52.3
bar=donor   line=cohort median 		225.8 207.4 9.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.0
bar=donor   line=cohort median 		2.2 2.4 65.0%
6 FCGR3B protein_coding 172.4
bar=donor   line=cohort median 		157.0 129.3 65.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 2,282.2
bar=donor   line=cohort median 		802.6 706.2 99.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 21.3
bar=donor   line=cohort median 		56.8 56.4 2.8%
9 CD3E protein_coding 15.4
bar=donor   line=cohort median 		36.9 37.7 2.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.0
bar=donor   line=cohort median 		3.2 3.1 16.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 206.2
bar=donor   line=cohort median 		296.3 281.6 26.7%
12 GNLY protein_coding 67.3
bar=donor   line=cohort median 		77.5 70.7 43.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,048.8
bar=donor   line=cohort median 		509.6 582.1 72.3%
14 HBA1 protein_coding 4,304.4
bar=donor   line=cohort median 		1,931.5 1,960.7 74.9%
15 HBA2 protein_coding 1,663.7
bar=donor   line=cohort median 		1,068.0 1,083.5 66.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,276.6
bar=donor   line=cohort median 		7,011.1 6,938.4 6.5%
17 MT-CO2 protein_coding 3,538.4
bar=donor   line=cohort median 		5,968.9 5,810.8 6.0%
18 MT-ND1 protein_coding 1,706.5
bar=donor   line=cohort median 		3,670.4 3,718.2 4.9%
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