GSM6881333

Dataset: gse221521 • Sample: DM group RNA466 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,312,178 Total counts Group median: 12,709,871 • 37.6%ile (≈ Median)
26,618 Detected genes Group median: 2,638 • 56.2%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 73.8%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

56.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 17.99
bar=donor   line=cohort median 		12.92 84.7%
CETP Lipid Metabolism 0.46
bar=donor   line=cohort median 		0.40 63.5%
SIRT6 Sirtuin Family 3.67
bar=donor   line=cohort median 		3.67 49.5%
SIRT1 Sirtuin Family 3.16
bar=donor   line=cohort median 		3.48 34.5%
SIRT3 Sirtuin Family 1.15
bar=donor   line=cohort median 		1.10 57.8%
IGF1R Insulin/IGF-1 Signaling 5.59
bar=donor   line=cohort median 		4.33 72.8%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 63.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.39
bar=donor   line=cohort median 		0.07 98.2%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 45.9%
IRS2 Insulin/IGF-1 Signaling 106.51
bar=donor   line=cohort median 		35.28 97.2%
TP53 Tumor Suppression 2.67
bar=donor   line=cohort median 		3.83 15.3%
SHC1 Signal Transduction 8.28
bar=donor   line=cohort median 		8.77 32.9%
ACE Signal Transduction 0.54
bar=donor   line=cohort median 		0.39 75.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,416.4 101,706
2 MT-RNR2 ENSG00000210082 Mt_rRNA 10,742.3 206,196
3 MT-CO1 ENSG00000198804 protein_coding 8,105.7 153,889
4 MT-CO2 ENSG00000198712 protein_coding 7,775.3 65,480
5 MT-CO3 ENSG00000198938 protein_coding 7,112.5 68,655
6 FTL ENSG00000087086 protein_coding 5,761.9 61,790
7 MT-RNR1 ENSG00000211459 Mt_rRNA 5,254.8 61,722
8 MT-ND1 ENSG00000198888 protein_coding 4,758.7 56,012
9 MT-ND4 ENSG00000198886 protein_coding 4,621.3 78,406
10 MT-ND3 ENSG00000198840 protein_coding 4,453.3 18,971

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,380.0
bar=donor   line=cohort median 		1,568.6 1,385.4 49.5%
2 S100A9 protein_coding 14,416.4
bar=donor   line=cohort median 		10,144.6 9,235.1 80.6%
3 IL1B protein_coding 2.9
bar=donor   line=cohort median 		6.9 6.1 14.8%
4 CXCL8 protein_coding 320.1
bar=donor   line=cohort median 		225.8 207.4 70.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 6.2
bar=donor   line=cohort median 		2.2 2.4 83.7%
6 FCGR3B protein_coding 73.4
bar=donor   line=cohort median 		157.0 129.3 18.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,149.3
bar=donor   line=cohort median 		802.6 706.2 80.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 43.1
bar=donor   line=cohort median 		56.8 56.4 29.3%
9 CD3E protein_coding 31.8
bar=donor   line=cohort median 		36.9 37.7 30.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.2
bar=donor   line=cohort median 		3.2 3.1 83.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 139.5
bar=donor   line=cohort median 		296.3 281.6 10.6%
12 GNLY protein_coding 27.0
bar=donor   line=cohort median 		77.5 70.7 6.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 119.9
bar=donor   line=cohort median 		509.6 582.1 4.9%
14 HBA1 protein_coding 537.8
bar=donor   line=cohort median 		1,931.5 1,960.7 8.0%
15 HBA2 protein_coding 303.2
bar=donor   line=cohort median 		1,068.0 1,083.5 9.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,105.7
bar=donor   line=cohort median 		7,011.1 6,938.4 68.7%
17 MT-CO2 protein_coding 7,775.3
bar=donor   line=cohort median 		5,968.9 5,810.8 76.4%
18 MT-ND1 protein_coding 4,758.7
bar=donor   line=cohort median 		3,670.4 3,718.2 76.9%
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