GSM6881334

Dataset: gse221521 • Sample: Control group RNA469 • Status: Healthy control
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Quality Control Metrics

13,212,674 Total counts Group median: 12,762,148 • 70.7%ile (≈ Median)
27,251 Detected genes Group median: 2,606 • 71.8%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 75.9%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

47.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.08
bar=donor   line=cohort median 		0.17 22.5%
FOXO3 Insulin/IGF-1 Signaling 15.31
bar=donor   line=cohort median 		12.92 66.6%
CETP Lipid Metabolism 0.41
bar=donor   line=cohort median 		0.40 53.6%
SIRT6 Sirtuin Family 3.37
bar=donor   line=cohort median 		3.67 32.9%
SIRT1 Sirtuin Family 3.98
bar=donor   line=cohort median 		3.48 69.7%
SIRT3 Sirtuin Family 0.90
bar=donor   line=cohort median 		1.10 18.4%
IGF1R Insulin/IGF-1 Signaling 6.68
bar=donor   line=cohort median 		4.33 85.2%
KLOTHO Anti-aging 0.03
bar=donor   line=cohort median 		0.06 25.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.27
bar=donor   line=cohort median 		0.07 94.6%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 86.62
bar=donor   line=cohort median 		35.28 96.1%
TP53 Tumor Suppression 2.78
bar=donor   line=cohort median 		3.83 17.4%
SHC1 Signal Transduction 8.53
bar=donor   line=cohort median 		8.77 41.2%
ACE Signal Transduction 0.19
bar=donor   line=cohort median 		0.39 14.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 10,426.6 212,431
2 S100A9 ENSG00000163220 protein_coding 9,108.1 68,956
3 MT-RNR2 ENSG00000210082 Mt_rRNA 8,333.5 171,658
4 MT-CO2 ENSG00000198712 protein_coding 8,280.0 74,830
5 MT-CO3 ENSG00000198938 protein_coding 7,947.2 82,323
6 MT-RNR1 ENSG00000211459 Mt_rRNA 5,330.9 67,196
7 MT-ND4 ENSG00000198886 protein_coding 4,705.6 85,675
8 FTL ENSG00000087086 protein_coding 4,584.1 52,755
9 MT-ATP8 ENSG00000228253 protein_coding 4,031.8 11,027
10 MT-ND3 ENSG00000198840 protein_coding 3,937.1 17,999

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,331.6
bar=donor   line=cohort median 		1,535.8 1,385.4 45.9%
2 S100A9 protein_coding 9,108.1
bar=donor   line=cohort median 		10,851.3 9,235.1 49.5%
3 IL1B protein_coding 5.2
bar=donor   line=cohort median 		5.6 6.1 43.3%
4 CXCL8 protein_coding 134.1
bar=donor   line=cohort median 		220.4 207.4 27.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 4.0
bar=donor   line=cohort median 		1.7 2.4 77.5%
6 FCGR3B protein_coding 207.3
bar=donor   line=cohort median 		145.0 129.3 78.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 711.5
bar=donor   line=cohort median 		709.1 706.2 51.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 50.7
bar=donor   line=cohort median 		66.1 56.4 42.2%
9 CD3E protein_coding 28.0
bar=donor   line=cohort median 		37.6 37.7 21.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.2
bar=donor   line=cohort median 		3.1 3.1 4.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 441.4
bar=donor   line=cohort median 		302.3 281.6 82.1%
12 GNLY protein_coding 61.3
bar=donor   line=cohort median 		80.1 70.7 38.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 73.7
bar=donor   line=cohort median 		598.7 582.1 2.8%
14 HBA1 protein_coding 234.1
bar=donor   line=cohort median 		2,133.6 1,960.7 0.8%
15 HBA2 protein_coding 122.0
bar=donor   line=cohort median 		1,142.2 1,083.5 1.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 10,426.6
bar=donor   line=cohort median 		6,862.1 6,938.4 93.0%
17 MT-CO2 protein_coding 8,280.0
bar=donor   line=cohort median 		6,023.6 5,810.8 83.2%
18 MT-ND1 protein_coding 3,698.8
bar=donor   line=cohort median 		3,656.3 3,718.2 49.0%
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