GSM6881335

Dataset: gse221521 • Sample: Control group RNA47 • Status: Healthy control
◂ Prev All Donors Next ▸

Quality Control Metrics

12,382,252 Total counts Group median: 12,762,148 • 41.2%ile (≈ Median)
23,934 Detected genes Group median: 2,606 • 4.9%ile (↓ Low)
10 Mitochondrial fraction (%) Group median: 6 • 94.6%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

50.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.09
bar=donor   line=cohort median 		0.17 25.7%
FOXO3 Insulin/IGF-1 Signaling 14.11
bar=donor   line=cohort median 		12.92 58.3%
CETP Lipid Metabolism 0.70
bar=donor   line=cohort median 		0.40 89.9%
SIRT6 Sirtuin Family 3.48
bar=donor   line=cohort median 		3.67 39.6%
SIRT1 Sirtuin Family 4.30
bar=donor   line=cohort median 		3.48 76.9%
SIRT3 Sirtuin Family 1.50
bar=donor   line=cohort median 		1.10 93.5%
IGF1R Insulin/IGF-1 Signaling 0.41
bar=donor   line=cohort median 		4.33 1.3%
KLOTHO Anti-aging 0.11
bar=donor   line=cohort median 		0.06 75.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.10
bar=donor   line=cohort median 		0.07 66.6%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 27.75
bar=donor   line=cohort median 		35.28 36.5%
TP53 Tumor Suppression 3.62
bar=donor   line=cohort median 		3.83 42.8%
SHC1 Signal Transduction 6.75
bar=donor   line=cohort median 		8.77 3.9%
ACE Signal Transduction 0.61
bar=donor   line=cohort median 		0.39 82.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 19,161.9 369,900
2 MT-RNR1 ENSG00000211459 Mt_rRNA 11,379.1 134,417
3 MT-CO2 ENSG00000198712 protein_coding 9,752.8 82,601
4 MT-ATP6 ENSG00000198899 protein_coding 9,700.9 81,801
5 TMSB4XP8 ENSG00000187653 processed_pseudogene 9,292.3 15,533
6 MT-CO1 ENSG00000198804 protein_coding 8,603.3 164,266
7 MT-ND1 ENSG00000198888 protein_coding 7,712.2 91,293
8 MT-CO3 ENSG00000198938 protein_coding 6,304.7 61,204
9 FTL ENSG00000087086 protein_coding 6,193.6 66,798
10 S100A9 ENSG00000163220 protein_coding 5,790.8 41,086

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,310.7
bar=donor   line=cohort median 		1,535.8 1,385.4 43.8%
2 S100A9 protein_coding 5,790.8
bar=donor   line=cohort median 		10,851.3 9,235.1 18.4%
3 IL1B protein_coding 8.0
bar=donor   line=cohort median 		5.6 6.1 66.1%
4 CXCL8 protein_coding 625.4
bar=donor   line=cohort median 		220.4 207.4 93.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.3
bar=donor   line=cohort median 		1.7 2.4 2.3%
6 FCGR3B protein_coding 146.7
bar=donor   line=cohort median 		145.0 129.3 56.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 405.1
bar=donor   line=cohort median 		709.1 706.2 17.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 79.5
bar=donor   line=cohort median 		66.1 56.4 75.9%
9 CD3E protein_coding 74.7
bar=donor   line=cohort median 		37.6 37.7 92.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.8
bar=donor   line=cohort median 		3.1 3.1 13.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 308.2
bar=donor   line=cohort median 		302.3 281.6 58.3%
12 GNLY protein_coding 127.4
bar=donor   line=cohort median 		80.1 70.7 85.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 305.0
bar=donor   line=cohort median 		598.7 582.1 24.6%
14 HBA1 protein_coding 740.3
bar=donor   line=cohort median 		2,133.6 1,960.7 18.4%
15 HBA2 protein_coding 419.0
bar=donor   line=cohort median 		1,142.2 1,083.5 16.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,603.3
bar=donor   line=cohort median 		6,862.1 6,938.4 78.5%
17 MT-CO2 protein_coding 9,752.8
bar=donor   line=cohort median 		6,023.6 5,810.8 91.5%
18 MT-ND1 protein_coding 7,712.2
bar=donor   line=cohort median 		3,656.3 3,718.2 96.1%
◂ Previous Donor Back to Donor List Next Donor ▸