GSM6881336

Dataset: gse221521 • Sample: DM group RNA471 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

18,428,869 Total counts Group median: 12,709,871 • 98.2%ile (↑ High)
28,900 Detected genes Group median: 2,638 • 97.7%ile (↑ High)
4 Mitochondrial fraction (%) Group median: 6 • 4.9%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

50.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.17
bar=donor   line=cohort median 		0.17 52.6%
FOXO3 Insulin/IGF-1 Signaling 16.93
bar=donor   line=cohort median 		12.92 78.0%
CETP Lipid Metabolism 0.36
bar=donor   line=cohort median 		0.40 41.2%
SIRT6 Sirtuin Family 3.57
bar=donor   line=cohort median 		3.67 43.8%
SIRT1 Sirtuin Family 3.63
bar=donor   line=cohort median 		3.48 59.8%
SIRT3 Sirtuin Family 1.14
bar=donor   line=cohort median 		1.10 56.2%
IGF1R Insulin/IGF-1 Signaling 5.70
bar=donor   line=cohort median 		4.33 74.9%
KLOTHO Anti-aging 0.05
bar=donor   line=cohort median 		0.06 39.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.08
bar=donor   line=cohort median 		0.07 54.7%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 57.03
bar=donor   line=cohort median 		35.28 78.5%
TP53 Tumor Suppression 3.45
bar=donor   line=cohort median 		3.83 37.1%
SHC1 Signal Transduction 9.25
bar=donor   line=cohort median 		8.77 65.5%
ACE Signal Transduction 0.13
bar=donor   line=cohort median 		0.39 3.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 9,849.7 104,010
2 MT-RNR2 ENSG00000210082 Mt_rRNA 4,560.1 131,015
3 MT-CO1 ENSG00000198804 protein_coding 4,063.4 115,470
4 MT-ATP6 ENSG00000198899 protein_coding 3,381.3 42,436
5 FTL ENSG00000087086 protein_coding 3,350.8 53,785
6 MT-CO2 ENSG00000198712 protein_coding 2,979.5 37,557
7 MT-ND3 ENSG00000198840 protein_coding 2,676.1 17,064
8 MT-CO3 ENSG00000198938 protein_coding 2,548.3 36,819
9 MT-ATP8 ENSG00000228253 protein_coding 2,395.2 9,137
10 MT-ND4 ENSG00000198886 protein_coding 2,370.5 60,200

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,000.8
bar=donor   line=cohort median 		1,568.6 1,385.4 75.9%
2 S100A9 protein_coding 9,849.7
bar=donor   line=cohort median 		10,144.6 9,235.1 56.2%
3 IL1B protein_coding 13.2
bar=donor   line=cohort median 		6.9 6.1 87.3%
4 CXCL8 protein_coding 344.8
bar=donor   line=cohort median 		225.8 207.4 74.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.2
bar=donor   line=cohort median 		2.2 2.4 23.6%
6 FCGR3B protein_coding 166.5
bar=donor   line=cohort median 		157.0 129.3 64.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,748.2
bar=donor   line=cohort median 		802.6 706.2 96.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 38.6
bar=donor   line=cohort median 		56.8 56.4 19.4%
9 CD3E protein_coding 29.7
bar=donor   line=cohort median 		36.9 37.7 25.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.4
bar=donor   line=cohort median 		3.2 3.1 55.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 348.7
bar=donor   line=cohort median 		296.3 281.6 68.7%
12 GNLY protein_coding 123.0
bar=donor   line=cohort median 		77.5 70.7 84.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 219.9
bar=donor   line=cohort median 		509.6 582.1 16.8%
14 HBA1 protein_coding 514.7
bar=donor   line=cohort median 		1,931.5 1,960.7 7.0%
15 HBA2 protein_coding 314.3
bar=donor   line=cohort median 		1,068.0 1,083.5 11.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,063.4
bar=donor   line=cohort median 		7,011.1 6,938.4 5.4%
17 MT-CO2 protein_coding 2,979.5
bar=donor   line=cohort median 		5,968.9 5,810.8 3.4%
18 MT-ND1 protein_coding 2,217.4
bar=donor   line=cohort median 		3,670.4 3,718.2 9.6%
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