GSM6881338

Dataset: gse221521 • Sample: DM group RNA476 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,119,617 Total counts Group median: 12,709,871 • 11.7%ile (↓ Low)
26,475 Detected genes Group median: 2,638 • 50.5%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 66.1%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

54.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.29
bar=donor   line=cohort median 		0.17 78.5%
FOXO3 Insulin/IGF-1 Signaling 15.16
bar=donor   line=cohort median 		12.92 65.5%
CETP Lipid Metabolism 0.74
bar=donor   line=cohort median 		0.40 91.5%
SIRT6 Sirtuin Family 3.40
bar=donor   line=cohort median 		3.67 34.5%
SIRT1 Sirtuin Family 3.22
bar=donor   line=cohort median 		3.48 36.5%
SIRT3 Sirtuin Family 1.02
bar=donor   line=cohort median 		1.10 36.0%
IGF1R Insulin/IGF-1 Signaling 5.09
bar=donor   line=cohort median 		4.33 64.0%
KLOTHO Anti-aging 0.26
bar=donor   line=cohort median 		0.06 98.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.04
bar=donor   line=cohort median 		0.07 35.0%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 26.78
bar=donor   line=cohort median 		35.28 34.5%
TP53 Tumor Suppression 2.42
bar=donor   line=cohort median 		3.83 8.6%
SHC1 Signal Transduction 9.96
bar=donor   line=cohort median 		8.77 84.7%
ACE Signal Transduction 0.71
bar=donor   line=cohort median 		0.39 88.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 11,411.5 197,824
2 S100A9 ENSG00000163220 protein_coding 10,894.4 69,414
3 MT-CO1 ENSG00000198804 protein_coding 6,527.8 111,929
4 MT-RNR1 ENSG00000211459 Mt_rRNA 6,100.3 64,713
5 MT-CO2 ENSG00000198712 protein_coding 6,063.3 46,116
6 MT-ATP6 ENSG00000198899 protein_coding 5,141.7 38,935
7 MT-ATP8 ENSG00000228253 protein_coding 4,921.4 11,328
8 FTL ENSG00000087086 protein_coding 4,417.3 42,782
9 MT-CO3 ENSG00000198938 protein_coding 4,285.5 37,360
10 MT-ND4L ENSG00000212907 protein_coding 3,648.1 12,048

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,886.9
bar=donor   line=cohort median 		1,568.6 1,385.4 71.8%
2 S100A9 protein_coding 10,894.4
bar=donor   line=cohort median 		10,144.6 9,235.1 61.9%
3 IL1B protein_coding 7.6
bar=donor   line=cohort median 		6.9 6.1 65.0%
4 CXCL8 protein_coding 245.2
bar=donor   line=cohort median 		225.8 207.4 55.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.7
bar=donor   line=cohort median 		2.2 2.4 58.3%
6 FCGR3B protein_coding 127.0
bar=donor   line=cohort median 		157.0 129.3 47.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 663.9
bar=donor   line=cohort median 		802.6 706.2 45.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 56.2
bar=donor   line=cohort median 		56.8 56.4 49.5%
9 CD3E protein_coding 40.4
bar=donor   line=cohort median 		36.9 37.7 58.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.7
bar=donor   line=cohort median 		3.2 3.1 79.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 312.4
bar=donor   line=cohort median 		296.3 281.6 59.3%
12 GNLY protein_coding 93.2
bar=donor   line=cohort median 		77.5 70.7 65.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 220.3
bar=donor   line=cohort median 		509.6 582.1 17.4%
14 HBA1 protein_coding 1,187.0
bar=donor   line=cohort median 		1,931.5 1,960.7 33.4%
15 HBA2 protein_coding 510.7
bar=donor   line=cohort median 		1,068.0 1,083.5 23.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,527.8
bar=donor   line=cohort median 		7,011.1 6,938.4 40.7%
17 MT-CO2 protein_coding 6,063.3
bar=donor   line=cohort median 		5,968.9 5,810.8 54.1%
18 MT-ND1 protein_coding 3,596.3
bar=donor   line=cohort median 		3,670.4 3,718.2 44.8%
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