GSM6881339

Dataset: gse221521 • Sample: Control group RNA479 • Status: Healthy control
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Quality Control Metrics

13,099,045 Total counts Group median: 12,762,148 • 66.1%ile (≈ Median)
26,027 Detected genes Group median: 2,606 • 34.5%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 23.6%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

53.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.24
bar=donor   line=cohort median 		0.17 72.8%
FOXO3 Insulin/IGF-1 Signaling 14.92
bar=donor   line=cohort median 		12.92 64.0%
CETP Lipid Metabolism 0.25
bar=donor   line=cohort median 		0.40 18.4%
SIRT6 Sirtuin Family 3.78
bar=donor   line=cohort median 		3.67 55.2%
SIRT1 Sirtuin Family 3.59
bar=donor   line=cohort median 		3.48 58.3%
SIRT3 Sirtuin Family 1.13
bar=donor   line=cohort median 		1.10 55.2%
IGF1R Insulin/IGF-1 Signaling 3.61
bar=donor   line=cohort median 		4.33 41.7%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 12.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.29
bar=donor   line=cohort median 		0.07 95.1%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 55.2%
IRS2 Insulin/IGF-1 Signaling 46.10
bar=donor   line=cohort median 		35.28 66.1%
TP53 Tumor Suppression 3.79
bar=donor   line=cohort median 		3.83 47.9%
SHC1 Signal Transduction 10.28
bar=donor   line=cohort median 		8.77 89.4%
ACE Signal Transduction 0.24
bar=donor   line=cohort median 		0.39 24.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,906.6 111,885
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,072.9 144,438
3 MT-CO1 ENSG00000198804 protein_coding 5,847.8 118,118
4 FTL ENSG00000087086 protein_coding 5,174.2 59,034
5 MT-CO2 ENSG00000198712 protein_coding 4,908.7 43,981
6 MT-CO3 ENSG00000198938 protein_coding 4,421.0 45,402
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,213.6 52,655
8 MT-ND1 ENSG00000198888 protein_coding 3,158.7 39,556
9 MT-ATP8 ENSG00000228253 protein_coding 3,075.4 8,339
10 MT-ND4 ENSG00000198886 protein_coding 2,957.5 53,384

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,654.4
bar=donor   line=cohort median 		1,535.8 1,385.4 58.8%
2 S100A9 protein_coding 14,906.6
bar=donor   line=cohort median 		10,851.3 9,235.1 83.2%
3 IL1B protein_coding 9.2
bar=donor   line=cohort median 		5.6 6.1 73.3%
4 CXCL8 protein_coding 517.3
bar=donor   line=cohort median 		220.4 207.4 89.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.3
bar=donor   line=cohort median 		1.7 2.4 49.5%
6 FCGR3B protein_coding 129.3
bar=donor   line=cohort median 		145.0 129.3 50.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 999.0
bar=donor   line=cohort median 		709.1 706.2 72.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 72.2
bar=donor   line=cohort median 		66.1 56.4 68.7%
9 CD3E protein_coding 37.9
bar=donor   line=cohort median 		37.6 37.7 50.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.3
bar=donor   line=cohort median 		3.1 3.1 6.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 343.4
bar=donor   line=cohort median 		302.3 281.6 67.6%
12 GNLY protein_coding 79.1
bar=donor   line=cohort median 		80.1 70.7 55.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 221.9
bar=donor   line=cohort median 		598.7 582.1 17.9%
14 HBA1 protein_coding 681.0
bar=donor   line=cohort median 		2,133.6 1,960.7 15.3%
15 HBA2 protein_coding 411.7
bar=donor   line=cohort median 		1,142.2 1,083.5 16.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,847.8
bar=donor   line=cohort median 		6,862.1 6,938.4 27.7%
17 MT-CO2 protein_coding 4,908.7
bar=donor   line=cohort median 		6,023.6 5,810.8 24.6%
18 MT-ND1 protein_coding 3,158.7
bar=donor   line=cohort median 		3,656.3 3,718.2 30.8%
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