GSM6881340

Dataset: gse221521 • Sample: Control group RNA48 • Status: Healthy control
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Quality Control Metrics

13,696,897 Total counts Group median: 12,762,148 • 80.6%ile (↑ High)
17,583 Detected genes Group median: 2,606 • 1.3%ile (↓ Low)
5 Mitochondrial fraction (%) Group median: 6 • 19.9%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

29.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 0.55
bar=donor   line=cohort median 		12.92 0.3%
CETP Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.40 0.5%
SIRT6 Sirtuin Family 0.76
bar=donor   line=cohort median 		3.67 0.3%
SIRT1 Sirtuin Family 8.09
bar=donor   line=cohort median 		3.48 99.7%
SIRT3 Sirtuin Family 1.30
bar=donor   line=cohort median 		1.10 80.1%
IGF1R Insulin/IGF-1 Signaling 0.56
bar=donor   line=cohort median 		4.33 5.4%
KLOTHO Anti-aging 0.10
bar=donor   line=cohort median 		0.06 70.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 4.89
bar=donor   line=cohort median 		35.28 1.3%
TP53 Tumor Suppression 6.64
bar=donor   line=cohort median 		3.83 97.2%
SHC1 Signal Transduction 6.33
bar=donor   line=cohort median 		8.77 2.3%
ACE Signal Transduction 0.14
bar=donor   line=cohort median 		0.39 6.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 15,041.5 321,188
2 MT-CO1 ENSG00000198804 protein_coding 8,499.2 179,509
3 IGKC ENSG00000211592 IG_C_gene 7,520.8 53,875
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 6,905.1 12,768
5 EEF1A1P5 ENSG00000196205 processed_pseudogene 4,653.8 88,538
6 AC113935.1 ENSG00000226084 processed_pseudogene 4,475.8 34,024
7 RPS28P7 ENSG00000227097 processed_pseudogene 4,115.3 11,837
8 RPL13AP5 ENSG00000236552 processed_pseudogene 4,032.2 33,800
9 RPL21P16 ENSG00000220842 processed_pseudogene 3,392.4 22,443
10 RPS12 ENSG00000112306 protein_coding 3,243.2 33,583

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 391.1
bar=donor   line=cohort median 		1,535.8 1,385.4 3.9%
2 S100A9 protein_coding 1,407.1
bar=donor   line=cohort median 		10,851.3 9,235.1 2.3%
3 IL1B protein_coding 3.7
bar=donor   line=cohort median 		5.6 6.1 24.1%
4 CXCL8 protein_coding 61.1
bar=donor   line=cohort median 		220.4 207.4 10.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.0
bar=donor   line=cohort median 		1.7 2.4 0.5%
6 FCGR3B protein_coding 77.8
bar=donor   line=cohort median 		145.0 129.3 22.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 290.9
bar=donor   line=cohort median 		709.1 706.2 11.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 190.6
bar=donor   line=cohort median 		66.1 56.4 99.7%
9 CD3E protein_coding 45.4
bar=donor   line=cohort median 		37.6 37.7 69.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 54.0
bar=donor   line=cohort median 		3.1 3.1 99.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 232.0
bar=donor   line=cohort median 		302.3 281.6 32.9%
12 GNLY protein_coding 14.6
bar=donor   line=cohort median 		80.1 70.7 0.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 354.7
bar=donor   line=cohort median 		598.7 582.1 29.3%
14 HBA1 protein_coding 629.2
bar=donor   line=cohort median 		2,133.6 1,960.7 13.2%
15 HBA2 protein_coding 221.1
bar=donor   line=cohort median 		1,142.2 1,083.5 5.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,499.2
bar=donor   line=cohort median 		6,862.1 6,938.4 76.4%
17 MT-CO2 protein_coding 2,344.1
bar=donor   line=cohort median 		6,023.6 5,810.8 1.8%
18 MT-ND1 protein_coding 551.5
bar=donor   line=cohort median 		3,656.3 3,718.2 1.3%
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