GSM6881341

Dataset: gse221521 • Sample: Control group RNA482 • Status: Healthy control
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Quality Control Metrics

13,547,516 Total counts Group median: 12,762,148 • 79.0%ile (↑ High)
25,774 Detected genes Group median: 2,606 • 26.2%ile (≈ Median)
4 Mitochondrial fraction (%) Group median: 6 • 9.1%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

53.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.27
bar=donor   line=cohort median 		0.17 76.4%
FOXO3 Insulin/IGF-1 Signaling 18.88
bar=donor   line=cohort median 		12.92 90.9%
CETP Lipid Metabolism 0.24
bar=donor   line=cohort median 		0.40 17.4%
SIRT6 Sirtuin Family 3.46
bar=donor   line=cohort median 		3.67 37.6%
SIRT1 Sirtuin Family 3.48
bar=donor   line=cohort median 		3.48 50.0%
SIRT3 Sirtuin Family 1.02
bar=donor   line=cohort median 		1.10 36.5%
IGF1R Insulin/IGF-1 Signaling 6.49
bar=donor   line=cohort median 		4.33 81.1%
KLOTHO Anti-aging 0.15
bar=donor   line=cohort median 		0.06 87.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.07
bar=donor   line=cohort median 		0.07 52.6%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 65.5%
IRS2 Insulin/IGF-1 Signaling 78.96
bar=donor   line=cohort median 		35.28 94.0%
TP53 Tumor Suppression 2.92
bar=donor   line=cohort median 		3.83 19.4%
SHC1 Signal Transduction 8.45
bar=donor   line=cohort median 		8.77 37.6%
ACE Signal Transduction 0.09
bar=donor   line=cohort median 		0.39 1.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 13,203.9 102,498
2 FTL ENSG00000087086 protein_coding 5,693.4 67,181
3 MT-CO1 ENSG00000198804 protein_coding 4,695.5 98,091
4 MT-CO2 ENSG00000198712 protein_coding 4,682.4 43,389
5 MT-ATP6 ENSG00000198899 protein_coding 4,589.4 42,341
6 MT-RNR2 ENSG00000210082 Mt_rRNA 3,966.1 83,766
7 MT-CO3 ENSG00000198938 protein_coding 3,560.6 37,818
8 EEF1A1P5 ENSG00000196205 processed_pseudogene 3,092.5 58,194
9 RPL13AP5 ENSG00000236552 processed_pseudogene 2,979.9 24,707
10 MT-ND4 ENSG00000198886 protein_coding 2,848.1 53,169

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,023.9
bar=donor   line=cohort median 		1,535.8 1,385.4 77.5%
2 S100A9 protein_coding 13,203.9
bar=donor   line=cohort median 		10,851.3 9,235.1 76.9%
3 IL1B protein_coding 2.1
bar=donor   line=cohort median 		5.6 6.1 9.6%
4 CXCL8 protein_coding 541.8
bar=donor   line=cohort median 		220.4 207.4 90.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.0
bar=donor   line=cohort median 		1.7 2.4 64.0%
6 FCGR3B protein_coding 222.5
bar=donor   line=cohort median 		145.0 129.3 84.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 697.1
bar=donor   line=cohort median 		709.1 706.2 47.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 47.8
bar=donor   line=cohort median 		66.1 56.4 34.5%
9 CD3E protein_coding 41.1
bar=donor   line=cohort median 		37.6 37.7 59.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.2
bar=donor   line=cohort median 		3.1 3.1 53.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 455.5
bar=donor   line=cohort median 		302.3 281.6 84.7%
12 GNLY protein_coding 105.8
bar=donor   line=cohort median 		80.1 70.7 73.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 479.6
bar=donor   line=cohort median 		598.7 582.1 43.3%
14 HBA1 protein_coding 1,635.8
bar=donor   line=cohort median 		2,133.6 1,960.7 41.7%
15 HBA2 protein_coding 751.1
bar=donor   line=cohort median 		1,142.2 1,083.5 35.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,695.5
bar=donor   line=cohort median 		6,862.1 6,938.4 8.5%
17 MT-CO2 protein_coding 4,682.4
bar=donor   line=cohort median 		6,023.6 5,810.8 20.5%
18 MT-ND1 protein_coding 2,248.7
bar=donor   line=cohort median 		3,656.3 3,718.2 10.1%
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