GSM6881342

Dataset: gse221521 • Sample: DM group RNA483 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

15,028,588 Total counts Group median: 12,709,871 • 92.0%ile (↑ High)
26,711 Detected genes Group median: 2,638 • 58.3%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 34.5%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

49.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.26
bar=donor   line=cohort median 		0.17 74.9%
FOXO3 Insulin/IGF-1 Signaling 15.93
bar=donor   line=cohort median 		12.92 72.8%
CETP Lipid Metabolism 0.28
bar=donor   line=cohort median 		0.40 23.1%
SIRT6 Sirtuin Family 3.47
bar=donor   line=cohort median 		3.67 39.1%
SIRT1 Sirtuin Family 3.44
bar=donor   line=cohort median 		3.48 45.9%
SIRT3 Sirtuin Family 0.83
bar=donor   line=cohort median 		1.10 11.1%
IGF1R Insulin/IGF-1 Signaling 7.20
bar=donor   line=cohort median 		4.33 90.4%
KLOTHO Anti-aging 0.11
bar=donor   line=cohort median 		0.06 77.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 43.8%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 63.45
bar=donor   line=cohort median 		35.28 84.2%
TP53 Tumor Suppression 3.11
bar=donor   line=cohort median 		3.83 24.6%
SHC1 Signal Transduction 8.59
bar=donor   line=cohort median 		8.77 44.3%
ACE Signal Transduction 0.37
bar=donor   line=cohort median 		0.39 48.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,149.8 121,849
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,003.6 210,950
3 MT-CO1 ENSG00000198804 protein_coding 5,878.5 136,229
4 FTL ENSG00000087086 protein_coding 5,809.0 76,039
5 MT-CO3 ENSG00000198938 protein_coding 5,270.7 62,102
6 MT-RNR1 ENSG00000211459 Mt_rRNA 5,268.0 75,529
7 MT-CO2 ENSG00000198712 protein_coding 4,596.5 47,250
8 MT-ND1 ENSG00000198888 protein_coding 3,475.1 49,928
9 MT-ND4 ENSG00000198886 protein_coding 3,205.2 66,378
10 MT-ND3 ENSG00000198840 protein_coding 2,775.3 14,431

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,544.5
bar=donor   line=cohort median 		1,568.6 1,385.4 55.2%
2 S100A9 protein_coding 14,149.8
bar=donor   line=cohort median 		10,144.6 9,235.1 79.0%
3 IL1B protein_coding 6.4
bar=donor   line=cohort median 		6.9 6.1 54.1%
4 CXCL8 protein_coding 313.0
bar=donor   line=cohort median 		225.8 207.4 68.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.2
bar=donor   line=cohort median 		2.2 2.4 48.4%
6 FCGR3B protein_coding 181.3
bar=donor   line=cohort median 		157.0 129.3 69.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 897.3
bar=donor   line=cohort median 		802.6 706.2 67.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 49.9
bar=donor   line=cohort median 		56.8 56.4 41.2%
9 CD3E protein_coding 34.6
bar=donor   line=cohort median 		36.9 37.7 41.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.7
bar=donor   line=cohort median 		3.2 3.1 11.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 250.1
bar=donor   line=cohort median 		296.3 281.6 40.7%
12 GNLY protein_coding 124.5
bar=donor   line=cohort median 		77.5 70.7 84.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 213.9
bar=donor   line=cohort median 		509.6 582.1 16.3%
14 HBA1 protein_coding 1,054.5
bar=donor   line=cohort median 		1,931.5 1,960.7 29.3%
15 HBA2 protein_coding 656.6
bar=donor   line=cohort median 		1,068.0 1,083.5 30.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,878.5
bar=donor   line=cohort median 		7,011.1 6,938.4 28.8%
17 MT-CO2 protein_coding 4,596.5
bar=donor   line=cohort median 		5,968.9 5,810.8 18.4%
18 MT-ND1 protein_coding 3,475.1
bar=donor   line=cohort median 		3,670.4 3,718.2 40.2%
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