GSM6881344

Dataset: gse221521 • Sample: Control group RNA484 • Status: Healthy control
◂ Prev All Donors Next ▸

Quality Control Metrics

14,388,195 Total counts Group median: 12,762,148 • 86.8%ile (↑ High)
27,340 Detected genes Group median: 2,606 • 73.8%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 67.1%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

50.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.31
bar=donor   line=cohort median 		0.17 84.2%
FOXO3 Insulin/IGF-1 Signaling 14.23
bar=donor   line=cohort median 		12.92 59.3%
CETP Lipid Metabolism 0.23
bar=donor   line=cohort median 		0.40 11.1%
SIRT6 Sirtuin Family 3.54
bar=donor   line=cohort median 		3.67 41.2%
SIRT1 Sirtuin Family 4.09
bar=donor   line=cohort median 		3.48 73.3%
SIRT3 Sirtuin Family 1.08
bar=donor   line=cohort median 		1.10 47.4%
IGF1R Insulin/IGF-1 Signaling 3.79
bar=donor   line=cohort median 		4.33 44.3%
KLOTHO Anti-aging 0.03
bar=donor   line=cohort median 		0.06 23.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.06
bar=donor   line=cohort median 		0.07 45.3%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 63.0%
IRS2 Insulin/IGF-1 Signaling 55.77
bar=donor   line=cohort median 		35.28 76.4%
TP53 Tumor Suppression 3.61
bar=donor   line=cohort median 		3.83 42.2%
SHC1 Signal Transduction 8.92
bar=donor   line=cohort median 		8.77 55.2%
ACE Signal Transduction 0.35
bar=donor   line=cohort median 		0.39 43.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 9,079.5 203,663
2 S100A9 ENSG00000163220 protein_coding 8,949.6 73,784
3 MT-CO1 ENSG00000198804 protein_coding 7,651.1 169,752
4 MT-CO2 ENSG00000198712 protein_coding 7,413.9 72,964
5 MT-CO3 ENSG00000198938 protein_coding 6,822.6 76,961
6 MT-ND4 ENSG00000198886 protein_coding 4,792.6 95,023
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,553.9 62,509
8 MT-ND3 ENSG00000198840 protein_coding 4,315.9 21,486
9 MT-ND1 ENSG00000198888 protein_coding 4,024.0 55,351
10 MT-ATP8 ENSG00000228253 protein_coding 3,764.5 11,212

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,354.1
bar=donor   line=cohort median 		1,535.8 1,385.4 47.4%
2 S100A9 protein_coding 8,949.6
bar=donor   line=cohort median 		10,851.3 9,235.1 48.4%
3 IL1B protein_coding 4.8
bar=donor   line=cohort median 		5.6 6.1 38.1%
4 CXCL8 protein_coding 64.4
bar=donor   line=cohort median 		220.4 207.4 10.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.4
bar=donor   line=cohort median 		1.7 2.4 28.2%
6 FCGR3B protein_coding 90.6
bar=donor   line=cohort median 		145.0 129.3 29.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 455.8
bar=donor   line=cohort median 		709.1 706.2 22.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 108.8
bar=donor   line=cohort median 		66.1 56.4 89.4%
9 CD3E protein_coding 55.9
bar=donor   line=cohort median 		37.6 37.7 83.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.4
bar=donor   line=cohort median 		3.1 3.1 31.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 446.7
bar=donor   line=cohort median 		302.3 281.6 83.7%
12 GNLY protein_coding 87.8
bar=donor   line=cohort median 		80.1 70.7 62.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 490.0
bar=donor   line=cohort median 		598.7 582.1 43.8%
14 HBA1 protein_coding 1,694.2
bar=donor   line=cohort median 		2,133.6 1,960.7 43.3%
15 HBA2 protein_coding 1,127.8
bar=donor   line=cohort median 		1,142.2 1,083.5 53.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,651.1
bar=donor   line=cohort median 		6,862.1 6,938.4 61.4%
17 MT-CO2 protein_coding 7,413.9
bar=donor   line=cohort median 		6,023.6 5,810.8 73.8%
18 MT-ND1 protein_coding 4,024.0
bar=donor   line=cohort median 		3,656.3 3,718.2 58.8%
◂ Previous Donor Back to Donor List Next Donor ▸