GSM6881345

Dataset: gse221521 • Sample: DM group RNA488 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,839,898 Total counts Group median: 12,709,871 • 83.2%ile (↑ High)
26,760 Detected genes Group median: 2,638 • 60.9%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 31.3%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

51.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.13
bar=donor   line=cohort median 		0.17 42.8%
FOXO3 Insulin/IGF-1 Signaling 16.43
bar=donor   line=cohort median 		12.92 76.4%
CETP Lipid Metabolism 0.41
bar=donor   line=cohort median 		0.40 52.6%
SIRT6 Sirtuin Family 3.64
bar=donor   line=cohort median 		3.67 48.5%
SIRT1 Sirtuin Family 2.55
bar=donor   line=cohort median 		3.48 10.1%
SIRT3 Sirtuin Family 1.12
bar=donor   line=cohort median 		1.10 53.1%
IGF1R Insulin/IGF-1 Signaling 6.24
bar=donor   line=cohort median 		4.33 80.1%
KLOTHO Anti-aging 0.05
bar=donor   line=cohort median 		0.06 40.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 27.2%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 52.6%
IRS2 Insulin/IGF-1 Signaling 57.80
bar=donor   line=cohort median 		35.28 79.0%
TP53 Tumor Suppression 3.60
bar=donor   line=cohort median 		3.83 41.7%
SHC1 Signal Transduction 9.23
bar=donor   line=cohort median 		8.77 65.0%
ACE Signal Transduction 0.44
bar=donor   line=cohort median 		0.39 58.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 10,348.2 82,064
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,011.0 151,272
3 MT-CO1 ENSG00000198804 protein_coding 6,476.2 138,210
4 FTL ENSG00000087086 protein_coding 6,010.2 72,450
5 MT-CO2 ENSG00000198712 protein_coding 5,702.7 53,985
6 MT-CO3 ENSG00000198938 protein_coding 5,536.3 60,072
7 MT-ND3 ENSG00000198840 protein_coding 4,229.8 20,255
8 MT-RNR1 ENSG00000211459 Mt_rRNA 3,735.5 49,321
9 MT-ND1 ENSG00000198888 protein_coding 3,386.3 44,804
10 MT-ND4 ENSG00000198886 protein_coding 3,298.6 62,909

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,959.7
bar=donor   line=cohort median 		1,568.6 1,385.4 74.4%
2 S100A9 protein_coding 10,348.2
bar=donor   line=cohort median 		10,144.6 9,235.1 59.3%
3 IL1B protein_coding 5.2
bar=donor   line=cohort median 		6.9 6.1 42.7%
4 CXCL8 protein_coding 831.0
bar=donor   line=cohort median 		225.8 207.4 97.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.1
bar=donor   line=cohort median 		2.2 2.4 65.5%
6 FCGR3B protein_coding 144.4
bar=donor   line=cohort median 		157.0 129.3 54.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,213.0
bar=donor   line=cohort median 		802.6 706.2 84.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 59.3
bar=donor   line=cohort median 		56.8 56.4 54.7%
9 CD3E protein_coding 33.1
bar=donor   line=cohort median 		36.9 37.7 35.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.2
bar=donor   line=cohort median 		3.2 3.1 24.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 268.0
bar=donor   line=cohort median 		296.3 281.6 44.8%
12 GNLY protein_coding 59.4
bar=donor   line=cohort median 		77.5 70.7 36.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 159.4
bar=donor   line=cohort median 		509.6 582.1 10.1%
14 HBA1 protein_coding 798.3
bar=donor   line=cohort median 		1,931.5 1,960.7 19.4%
15 HBA2 protein_coding 557.3
bar=donor   line=cohort median 		1,068.0 1,083.5 26.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,476.2
bar=donor   line=cohort median 		7,011.1 6,938.4 39.6%
17 MT-CO2 protein_coding 5,702.7
bar=donor   line=cohort median 		5,968.9 5,810.8 46.9%
18 MT-ND1 protein_coding 3,386.3
bar=donor   line=cohort median 		3,670.4 3,718.2 37.0%
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