GSM6881346

Dataset: gse221521 • Sample: Control group RNA49 • Status: Healthy control
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Quality Control Metrics

13,815,371 Total counts Group median: 12,762,148 • 82.6%ile (↑ High)
25,193 Detected genes Group median: 2,606 • 14.8%ile (↓ Low)
14 Mitochondrial fraction (%) Group median: 6 • 98.2%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

50.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.17
bar=donor   line=cohort median 		0.17 53.1%
FOXO3 Insulin/IGF-1 Signaling 3.52
bar=donor   line=cohort median 		12.92 2.3%
CETP Lipid Metabolism 0.91
bar=donor   line=cohort median 		0.40 95.6%
SIRT6 Sirtuin Family 2.90
bar=donor   line=cohort median 		3.67 16.8%
SIRT1 Sirtuin Family 3.89
bar=donor   line=cohort median 		3.48 67.6%
SIRT3 Sirtuin Family 1.17
bar=donor   line=cohort median 		1.10 59.8%
IGF1R Insulin/IGF-1 Signaling 3.44
bar=donor   line=cohort median 		4.33 39.6%
KLOTHO Anti-aging 0.15
bar=donor   line=cohort median 		0.06 89.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.12
bar=donor   line=cohort median 		0.07 76.9%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 9.18
bar=donor   line=cohort median 		35.28 6.5%
TP53 Tumor Suppression 5.63
bar=donor   line=cohort median 		3.83 88.3%
SHC1 Signal Transduction 8.77
bar=donor   line=cohort median 		8.77 50.0%
ACE Signal Transduction 0.37
bar=donor   line=cohort median 		0.39 47.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 23,485.1 505,826
2 MT-RNR1 ENSG00000211459 Mt_rRNA 15,313.7 201,832
3 MT-CO1 ENSG00000198804 protein_coding 14,351.5 305,734
4 MT-CO2 ENSG00000198712 protein_coding 12,889.4 121,801
5 TMSB4XP8 ENSG00000187653 processed_pseudogene 11,314.8 21,103
6 MT-CO3 ENSG00000198938 protein_coding 9,562.4 103,573
7 MT-ND1 ENSG00000198888 protein_coding 9,034.9 119,329
8 MT-ND4 ENSG00000198886 protein_coding 7,626.2 145,185
9 MT-ND3 ENSG00000198840 protein_coding 7,050.9 33,704
10 MT-ND2 ENSG00000198763 protein_coding 6,848.8 98,592

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 494.2
bar=donor   line=cohort median 		1,535.8 1,385.4 6.5%
2 S100A9 protein_coding 2,565.9
bar=donor   line=cohort median 		10,851.3 9,235.1 4.9%
3 IL1B protein_coding 4.8
bar=donor   line=cohort median 		5.6 6.1 38.6%
4 CXCL8 protein_coding 144.8
bar=donor   line=cohort median 		220.4 207.4 30.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.5
bar=donor   line=cohort median 		1.7 2.4 29.3%
6 FCGR3B protein_coding 29.5
bar=donor   line=cohort median 		145.0 129.3 7.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 606.9
bar=donor   line=cohort median 		709.1 706.2 40.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 63.5
bar=donor   line=cohort median 		66.1 56.4 59.8%
9 CD3E protein_coding 85.5
bar=donor   line=cohort median 		37.6 37.7 97.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 9.7
bar=donor   line=cohort median 		3.1 3.1 96.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 569.3
bar=donor   line=cohort median 		302.3 281.6 94.0%
12 GNLY protein_coding 169.5
bar=donor   line=cohort median 		80.1 70.7 93.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,118.8
bar=donor   line=cohort median 		598.7 582.1 74.4%
14 HBA1 protein_coding 2,885.3
bar=donor   line=cohort median 		2,133.6 1,960.7 64.0%
15 HBA2 protein_coding 1,604.8
bar=donor   line=cohort median 		1,142.2 1,083.5 65.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 14,351.5
bar=donor   line=cohort median 		6,862.1 6,938.4 98.7%
17 MT-CO2 protein_coding 12,889.4
bar=donor   line=cohort median 		6,023.6 5,810.8 98.7%
18 MT-ND1 protein_coding 9,034.9
bar=donor   line=cohort median 		3,656.3 3,718.2 97.2%
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