GSM6881347

Dataset: gse221521 • Sample: DM group RNA499 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,083,345 Total counts Group median: 12,709,871 • 65.0%ile (≈ Median)
26,856 Detected genes Group median: 2,638 • 62.4%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 39.6%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

41.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.10
bar=donor   line=cohort median 		0.17 31.9%
FOXO3 Insulin/IGF-1 Signaling 14.09
bar=donor   line=cohort median 		12.92 57.3%
CETP Lipid Metabolism 0.14
bar=donor   line=cohort median 		0.40 3.4%
SIRT6 Sirtuin Family 3.34
bar=donor   line=cohort median 		3.67 30.8%
SIRT1 Sirtuin Family 3.14
bar=donor   line=cohort median 		3.48 32.9%
SIRT3 Sirtuin Family 1.44
bar=donor   line=cohort median 		1.10 89.9%
IGF1R Insulin/IGF-1 Signaling 4.19
bar=donor   line=cohort median 		4.33 49.0%
KLOTHO Anti-aging 0.05
bar=donor   line=cohort median 		0.06 37.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.21
bar=donor   line=cohort median 		0.07 89.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 47.32
bar=donor   line=cohort median 		35.28 67.1%
TP53 Tumor Suppression 2.41
bar=donor   line=cohort median 		3.83 8.0%
SHC1 Signal Transduction 8.45
bar=donor   line=cohort median 		8.77 38.1%
ACE Signal Transduction 0.24
bar=donor   line=cohort median 		0.39 22.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,341.7 107,516
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,398.1 150,898
3 MT-CO1 ENSG00000198804 protein_coding 7,331.2 147,904
4 MT-CO3 ENSG00000198938 protein_coding 5,698.3 58,449
5 FTL ENSG00000087086 protein_coding 5,000.3 56,981
6 MT-CO2 ENSG00000198712 protein_coding 4,800.3 42,958
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,232.1 52,823
8 MT-ND3 ENSG00000198840 protein_coding 3,931.9 17,799
9 MT-ND1 ENSG00000198888 protein_coding 3,835.6 47,974
10 MT-ND4 ENSG00000198886 protein_coding 3,829.0 69,033

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,373.4
bar=donor   line=cohort median 		1,568.6 1,385.4 85.8%
2 S100A9 protein_coding 14,341.7
bar=donor   line=cohort median 		10,144.6 9,235.1 79.5%
3 IL1B protein_coding 4.5
bar=donor   line=cohort median 		6.9 6.1 36.0%
4 CXCL8 protein_coding 248.4
bar=donor   line=cohort median 		225.8 207.4 58.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.8
bar=donor   line=cohort median 		2.2 2.4 37.0%
6 FCGR3B protein_coding 257.1
bar=donor   line=cohort median 		157.0 129.3 89.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 808.5
bar=donor   line=cohort median 		802.6 706.2 59.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 49.2
bar=donor   line=cohort median 		56.8 56.4 38.6%
9 CD3E protein_coding 34.6
bar=donor   line=cohort median 		36.9 37.7 42.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.3
bar=donor   line=cohort median 		3.2 3.1 85.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 283.2
bar=donor   line=cohort median 		296.3 281.6 51.0%
12 GNLY protein_coding 42.6
bar=donor   line=cohort median 		77.5 70.7 18.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 476.7
bar=donor   line=cohort median 		509.6 582.1 42.7%
14 HBA1 protein_coding 907.4
bar=donor   line=cohort median 		1,931.5 1,960.7 23.6%
15 HBA2 protein_coding 555.1
bar=donor   line=cohort median 		1,068.0 1,083.5 26.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,331.2
bar=donor   line=cohort median 		7,011.1 6,938.4 56.2%
17 MT-CO2 protein_coding 4,800.3
bar=donor   line=cohort median 		5,968.9 5,810.8 22.5%
18 MT-ND1 protein_coding 3,835.6
bar=donor   line=cohort median 		3,670.4 3,718.2 53.6%
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