GSM6881348

Dataset: gse221521 • Sample: DR group RNA50 • Status: Diabetic retinopathy
◂ Prev All Donors Next ▸

Quality Control Metrics

13,461,164 Total counts Group median: 12,498,211 • 76.9%ile (↑ High)
24,275 Detected genes Group median: 27,368 • 7.5%ile (↓ Low)
16 Mitochondrial fraction (%) Group median: 6 • 99.7%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

45.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.37
bar=donor   line=cohort median 		0.17 92.5%
FOXO3 Insulin/IGF-1 Signaling 6.23
bar=donor   line=cohort median 		12.92 5.4%
CETP Lipid Metabolism 0.70
bar=donor   line=cohort median 		0.40 89.4%
SIRT6 Sirtuin Family 3.10
bar=donor   line=cohort median 		3.67 21.0%
SIRT1 Sirtuin Family 3.82
bar=donor   line=cohort median 		3.48 65.5%
SIRT3 Sirtuin Family 0.97
bar=donor   line=cohort median 		1.10 26.7%
IGF1R Insulin/IGF-1 Signaling 1.90
bar=donor   line=cohort median 		4.33 16.8%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 36.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.01
bar=donor   line=cohort median 		0.07 21.5%
TERT Telomere Maintenance 0.04
bar=donor   line=cohort median 		0.01 84.2%
IRS2 Insulin/IGF-1 Signaling 5.66
bar=donor   line=cohort median 		35.28 1.8%
TP53 Tumor Suppression 5.58
bar=donor   line=cohort median 		3.83 87.3%
SHC1 Signal Transduction 7.94
bar=donor   line=cohort median 		8.77 19.4%
ACE Signal Transduction 0.49
bar=donor   line=cohort median 		0.39 67.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 24,196.1 507,778
2 MT-ATP6 ENSG00000198899 protein_coding 15,949.6 146,211
3 MT-CO1 ENSG00000198804 protein_coding 15,485.7 321,439
4 MT-CO2 ENSG00000198712 protein_coding 14,786.7 136,148
5 MT-ND1 ENSG00000198888 protein_coding 14,576.9 187,588
6 MT-RNR1 ENSG00000211459 Mt_rRNA 11,608.1 149,071
7 TMSB4XP8 ENSG00000187653 processed_pseudogene 11,128.3 20,223
8 MT-CO3 ENSG00000198938 protein_coding 11,080.4 116,938
9 HBA1 ENSG00000206172 protein_coding 10,957.9 253,711
10 MT-ND4 ENSG00000198886 protein_coding 10,227.9 189,722

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 231.7
bar=donor   line=cohort median 		1,223.7 1,385.4 1.8%
2 S100A9 protein_coding 1,243.4
bar=donor   line=cohort median 		7,732.1 9,235.1 1.8%
3 IL1B protein_coding 1.5
bar=donor   line=cohort median 		4.9 6.1 6.5%
4 CXCL8 protein_coding 20.0
bar=donor   line=cohort median 		197.4 207.4 2.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.0
bar=donor   line=cohort median 		2.9 2.4 16.8%
6 FCGR3B protein_coding 7.8
bar=donor   line=cohort median 		108.9 129.3 0.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 605.3
bar=donor   line=cohort median 		581.4 706.2 39.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 77.6
bar=donor   line=cohort median 		51.6 56.4 73.8%
9 CD3E protein_coding 76.3
bar=donor   line=cohort median 		38.1 37.7 93.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 6.3
bar=donor   line=cohort median 		3.0 3.1 89.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 527.8
bar=donor   line=cohort median 		252.2 281.6 90.4%
12 GNLY protein_coding 146.3
bar=donor   line=cohort median 		58.9 70.7 90.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,326.9
bar=donor   line=cohort median 		585.0 582.1 82.1%
14 HBA1 protein_coding 10,957.9
bar=donor   line=cohort median 		1,960.4 1,960.7 95.1%
15 HBA2 protein_coding 4,266.5
bar=donor   line=cohort median 		1,080.5 1,083.5 89.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 15,485.7
bar=donor   line=cohort median 		6,740.9 6,938.4 99.7%
17 MT-CO2 protein_coding 14,786.7
bar=donor   line=cohort median 		5,693.7 5,810.8 99.7%
18 MT-ND1 protein_coding 14,576.9
bar=donor   line=cohort median 		3,876.8 3,718.2 99.7%
◂ Previous Donor Back to Donor List Next Donor ▸