GSM6881350

Dataset: gse221521 • Sample: Control group RNA500 • Status: Healthy control
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Quality Control Metrics

12,780,768 Total counts Group median: 12,762,148 • 56.2%ile (≈ Median)
27,692 Detected genes Group median: 2,606 • 82.1%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 32.4%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

46.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.23
bar=donor   line=cohort median 		0.17 69.2%
FOXO3 Insulin/IGF-1 Signaling 17.20
bar=donor   line=cohort median 		12.92 79.5%
CETP Lipid Metabolism 0.50
bar=donor   line=cohort median 		0.40 68.7%
SIRT6 Sirtuin Family 3.93
bar=donor   line=cohort median 		3.67 61.4%
SIRT1 Sirtuin Family 3.09
bar=donor   line=cohort median 		3.48 29.8%
SIRT3 Sirtuin Family 0.89
bar=donor   line=cohort median 		1.10 16.8%
IGF1R Insulin/IGF-1 Signaling 3.43
bar=donor   line=cohort median 		4.33 38.6%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 14.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 28.8%
TERT Telomere Maintenance 0.06
bar=donor   line=cohort median 		0.01 92.5%
IRS2 Insulin/IGF-1 Signaling 44.48
bar=donor   line=cohort median 		35.28 63.5%
TP53 Tumor Suppression 2.71
bar=donor   line=cohort median 		3.83 15.8%
SHC1 Signal Transduction 8.71
bar=donor   line=cohort median 		8.77 47.4%
ACE Signal Transduction 0.21
bar=donor   line=cohort median 		0.39 17.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 10,465.5 76,643
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,653.0 152,488
3 MT-CO1 ENSG00000198804 protein_coding 5,223.3 102,940
4 MT-CO2 ENSG00000198712 protein_coding 4,957.7 43,340
5 MT-ND3 ENSG00000198840 protein_coding 4,914.4 21,732
6 MT-CO3 ENSG00000198938 protein_coding 4,195.7 42,041
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,004.4 48,825
8 FTL ENSG00000087086 protein_coding 3,791.9 42,212
9 MT-ND4L ENSG00000212907 protein_coding 3,685.3 13,989
10 MT-ND4 ENSG00000198886 protein_coding 3,588.8 63,205

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,681.8
bar=donor   line=cohort median 		1,535.8 1,385.4 60.4%
2 S100A9 protein_coding 10,465.5
bar=donor   line=cohort median 		10,851.3 9,235.1 59.8%
3 IL1B protein_coding 5.2
bar=donor   line=cohort median 		5.6 6.1 43.8%
4 CXCL8 protein_coding 248.6
bar=donor   line=cohort median 		220.4 207.4 58.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.2
bar=donor   line=cohort median 		1.7 2.4 69.7%
6 FCGR3B protein_coding 158.7
bar=donor   line=cohort median 		145.0 129.3 63.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 742.9
bar=donor   line=cohort median 		709.1 706.2 55.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 77.0
bar=donor   line=cohort median 		66.1 56.4 73.3%
9 CD3E protein_coding 42.4
bar=donor   line=cohort median 		37.6 37.7 63.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.8
bar=donor   line=cohort median 		3.1 3.1 40.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 342.5
bar=donor   line=cohort median 		302.3 281.6 67.1%
12 GNLY protein_coding 69.0
bar=donor   line=cohort median 		80.1 70.7 46.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 582.1
bar=donor   line=cohort median 		598.7 582.1 50.0%
14 HBA1 protein_coding 2,099.5
bar=donor   line=cohort median 		2,133.6 1,960.7 53.1%
15 HBA2 protein_coding 1,156.7
bar=donor   line=cohort median 		1,142.2 1,083.5 54.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,223.3
bar=donor   line=cohort median 		6,862.1 6,938.4 15.8%
17 MT-CO2 protein_coding 4,957.7
bar=donor   line=cohort median 		6,023.6 5,810.8 25.6%
18 MT-ND1 protein_coding 3,129.2
bar=donor   line=cohort median 		3,656.3 3,718.2 29.8%
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