GSM6881351

Dataset: gse221521 • Sample: DM group RNA504 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

25,245,018 Total counts Group median: 12,709,871 • 99.7%ile (↑ High)
29,594 Detected genes Group median: 2,638 • 99.7%ile (↑ High)
8 Mitochondrial fraction (%) Group median: 6 • 79.0%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

50.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.22
bar=donor   line=cohort median 		0.17 67.1%
FOXO3 Insulin/IGF-1 Signaling 10.99
bar=donor   line=cohort median 		12.92 30.3%
CETP Lipid Metabolism 0.53
bar=donor   line=cohort median 		0.40 73.3%
SIRT6 Sirtuin Family 3.23
bar=donor   line=cohort median 		3.67 25.1%
SIRT1 Sirtuin Family 2.93
bar=donor   line=cohort median 		3.48 24.1%
SIRT3 Sirtuin Family 1.05
bar=donor   line=cohort median 		1.10 40.7%
IGF1R Insulin/IGF-1 Signaling 2.52
bar=donor   line=cohort median 		4.33 27.2%
KLOTHO Anti-aging 0.20
bar=donor   line=cohort median 		0.06 95.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.06
bar=donor   line=cohort median 		0.07 48.5%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 61.4%
IRS2 Insulin/IGF-1 Signaling 15.35
bar=donor   line=cohort median 		35.28 10.1%
TP53 Tumor Suppression 4.47
bar=donor   line=cohort median 		3.83 66.6%
SHC1 Signal Transduction 10.07
bar=donor   line=cohort median 		8.77 86.8%
ACE Signal Transduction 0.37
bar=donor   line=cohort median 		0.39 47.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 10,265.2 404,009
2 S100A9 ENSG00000163220 protein_coding 9,801.9 141,788
3 MT-CO1 ENSG00000198804 protein_coding 9,104.5 354,417
4 MT-CO2 ENSG00000198712 protein_coding 8,031.6 138,686
5 MT-CO3 ENSG00000198938 protein_coding 6,922.5 137,011
6 MT-ND3 ENSG00000198840 protein_coding 6,442.1 56,270
7 MT-RNR1 ENSG00000211459 Mt_rRNA 5,868.9 141,345
8 MT-ATP8 ENSG00000228253 protein_coding 5,480.0 28,637
9 HBA1 ENSG00000206172 protein_coding 5,267.8 228,737
10 MT-ND4L ENSG00000212907 protein_coding 5,200.3 38,991

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,544.5
bar=donor   line=cohort median 		1,568.6 1,385.4 55.7%
2 S100A9 protein_coding 9,801.9
bar=donor   line=cohort median 		10,144.6 9,235.1 55.2%
3 IL1B protein_coding 9.0
bar=donor   line=cohort median 		6.9 6.1 72.8%
4 CXCL8 protein_coding 196.0
bar=donor   line=cohort median 		225.8 207.4 44.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.4
bar=donor   line=cohort median 		2.2 2.4 50.0%
6 FCGR3B protein_coding 60.5
bar=donor   line=cohort median 		157.0 129.3 13.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,042.2
bar=donor   line=cohort median 		802.6 706.2 74.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 57.7
bar=donor   line=cohort median 		56.8 56.4 52.6%
9 CD3E protein_coding 24.7
bar=donor   line=cohort median 		36.9 37.7 13.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.4
bar=donor   line=cohort median 		3.2 3.1 58.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 469.1
bar=donor   line=cohort median 		296.3 281.6 85.8%
12 GNLY protein_coding 115.9
bar=donor   line=cohort median 		77.5 70.7 80.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,392.2
bar=donor   line=cohort median 		509.6 582.1 83.7%
14 HBA1 protein_coding 5,267.8
bar=donor   line=cohort median 		1,931.5 1,960.7 80.6%
15 HBA2 protein_coding 2,546.3
bar=donor   line=cohort median 		1,068.0 1,083.5 78.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,104.5
bar=donor   line=cohort median 		7,011.1 6,938.4 84.7%
17 MT-CO2 protein_coding 8,031.6
bar=donor   line=cohort median 		5,968.9 5,810.8 79.0%
18 MT-ND1 protein_coding 4,380.1
bar=donor   line=cohort median 		3,670.4 3,718.2 69.2%
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