GSM6881352

Dataset: gse221521 • Sample: Control group RNA505 • Status: Healthy control
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Quality Control Metrics

12,337,327 Total counts Group median: 12,762,148 • 39.1%ile (≈ Median)
26,747 Detected genes Group median: 2,606 • 59.8%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 31.9%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

48.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.19
bar=donor   line=cohort median 		0.17 59.3%
FOXO3 Insulin/IGF-1 Signaling 18.83
bar=donor   line=cohort median 		12.92 90.4%
CETP Lipid Metabolism 0.29
bar=donor   line=cohort median 		0.40 25.1%
SIRT6 Sirtuin Family 3.35
bar=donor   line=cohort median 		3.67 31.4%
SIRT1 Sirtuin Family 4.27
bar=donor   line=cohort median 		3.48 75.9%
SIRT3 Sirtuin Family 1.01
bar=donor   line=cohort median 		1.10 33.4%
IGF1R Insulin/IGF-1 Signaling 3.45
bar=donor   line=cohort median 		4.33 40.2%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 29.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 30.8%
TERT Telomere Maintenance 0.07
bar=donor   line=cohort median 		0.01 95.6%
IRS2 Insulin/IGF-1 Signaling 42.40
bar=donor   line=cohort median 		35.28 60.4%
TP53 Tumor Suppression 3.83
bar=donor   line=cohort median 		3.83 50.0%
SHC1 Signal Transduction 8.07
bar=donor   line=cohort median 		8.77 25.1%
ACE Signal Transduction 0.28
bar=donor   line=cohort median 		0.39 31.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 9,581.9 67,737
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,783.2 149,701
3 MT-CO1 ENSG00000198804 protein_coding 6,337.8 120,571
4 MT-CO3 ENSG00000198938 protein_coding 5,058.8 48,931
5 MT-CO2 ENSG00000198712 protein_coding 4,414.4 37,252
6 MT-RNR1 ENSG00000211459 Mt_rRNA 4,265.2 50,201
7 FTL ENSG00000087086 protein_coding 3,963.2 42,588
8 MT-ND4 ENSG00000198886 protein_coding 3,557.9 60,488
9 MT-ND3 ENSG00000198840 protein_coding 3,429.8 14,641
10 MT-ATP8 ENSG00000228253 protein_coding 3,217.9 8,218

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,508.7
bar=donor   line=cohort median 		1,535.8 1,385.4 54.1%
2 S100A9 protein_coding 9,581.9
bar=donor   line=cohort median 		10,851.3 9,235.1 52.1%
3 IL1B protein_coding 8.8
bar=donor   line=cohort median 		5.6 6.1 69.7%
4 CXCL8 protein_coding 480.9
bar=donor   line=cohort median 		220.4 207.4 88.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.7
bar=donor   line=cohort median 		1.7 2.4 8.0%
6 FCGR3B protein_coding 246.8
bar=donor   line=cohort median 		145.0 129.3 88.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 579.5
bar=donor   line=cohort median 		709.1 706.2 36.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 42.1
bar=donor   line=cohort median 		66.1 56.4 27.7%
9 CD3E protein_coding 26.9
bar=donor   line=cohort median 		37.6 37.7 17.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.0
bar=donor   line=cohort median 		3.1 3.1 83.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 138.7
bar=donor   line=cohort median 		302.3 281.6 10.1%
12 GNLY protein_coding 37.3
bar=donor   line=cohort median 		80.1 70.7 13.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 315.4
bar=donor   line=cohort median 		598.7 582.1 27.7%
14 HBA1 protein_coding 628.6
bar=donor   line=cohort median 		2,133.6 1,960.7 12.7%
15 HBA2 protein_coding 343.1
bar=donor   line=cohort median 		1,142.2 1,083.5 13.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,337.8
bar=donor   line=cohort median 		6,862.1 6,938.4 38.1%
17 MT-CO2 protein_coding 4,414.4
bar=donor   line=cohort median 		6,023.6 5,810.8 15.8%
18 MT-ND1 protein_coding 3,042.3
bar=donor   line=cohort median 		3,656.3 3,718.2 26.7%
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