GSM6881353

Dataset: gse221521 • Sample: Control group RNA51 • Status: Healthy control
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Quality Control Metrics

11,700,858 Total counts Group median: 12,762,148 • 20.5%ile (↓ Low)
24,023 Detected genes Group median: 2,606 • 5.4%ile (↓ Low)
16 Mitochondrial fraction (%) Group median: 6 • 99.2%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

42.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.11
bar=donor   line=cohort median 		0.17 36.0%
FOXO3 Insulin/IGF-1 Signaling 6.55
bar=donor   line=cohort median 		12.92 6.0%
CETP Lipid Metabolism 0.73
bar=donor   line=cohort median 		0.40 90.9%
SIRT6 Sirtuin Family 3.77
bar=donor   line=cohort median 		3.67 54.7%
SIRT1 Sirtuin Family 2.79
bar=donor   line=cohort median 		3.48 18.9%
SIRT3 Sirtuin Family 1.58
bar=donor   line=cohort median 		1.10 95.6%
IGF1R Insulin/IGF-1 Signaling 2.56
bar=donor   line=cohort median 		4.33 28.8%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 17.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.05
bar=donor   line=cohort median 		0.01 86.8%
IRS2 Insulin/IGF-1 Signaling 7.86
bar=donor   line=cohort median 		35.28 4.4%
TP53 Tumor Suppression 5.06
bar=donor   line=cohort median 		3.83 79.5%
SHC1 Signal Transduction 8.36
bar=donor   line=cohort median 		8.77 35.5%
ACE Signal Transduction 0.24
bar=donor   line=cohort median 		0.39 21.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 29,605.7 540,056
2 MT-RNR1 ENSG00000211459 Mt_rRNA 19,733.8 220,281
3 MT-CO2 ENSG00000198712 protein_coding 13,392.5 107,185
4 MT-ND1 ENSG00000198888 protein_coding 13,362.2 149,470
5 MT-CO3 ENSG00000198938 protein_coding 13,354.9 122,511
6 MT-CO1 ENSG00000198804 protein_coding 12,433.4 224,333
7 HBA1 ENSG00000206172 protein_coding 11,948.7 240,473
8 TMSB4XP8 ENSG00000187653 processed_pseudogene 8,969.9 14,169
9 MT-ND2 ENSG00000198763 protein_coding 8,176.6 99,691
10 MT-ND4 ENSG00000198886 protein_coding 7,899.2 127,365

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 482.7
bar=donor   line=cohort median 		1,535.8 1,385.4 5.4%
2 S100A9 protein_coding 2,646.8
bar=donor   line=cohort median 		10,851.3 9,235.1 5.4%
3 IL1B protein_coding 0.5
bar=donor   line=cohort median 		5.6 6.1 1.8%
4 CXCL8 protein_coding 44.5
bar=donor   line=cohort median 		220.4 207.4 7.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.3
bar=donor   line=cohort median 		1.7 2.4 2.8%
6 FCGR3B protein_coding 23.1
bar=donor   line=cohort median 		145.0 129.3 4.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 423.8
bar=donor   line=cohort median 		709.1 706.2 19.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 130.9
bar=donor   line=cohort median 		66.1 56.4 97.2%
9 CD3E protein_coding 99.0
bar=donor   line=cohort median 		37.6 37.7 98.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.2
bar=donor   line=cohort median 		3.1 3.1 74.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 469.1
bar=donor   line=cohort median 		302.3 281.6 85.2%
12 GNLY protein_coding 140.0
bar=donor   line=cohort median 		80.1 70.7 88.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,748.5
bar=donor   line=cohort median 		598.7 582.1 87.8%
14 HBA1 protein_coding 11,948.7
bar=donor   line=cohort median 		2,133.6 1,960.7 96.6%
15 HBA2 protein_coding 4,122.7
bar=donor   line=cohort median 		1,142.2 1,083.5 87.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 12,433.4
bar=donor   line=cohort median 		6,862.1 6,938.4 96.6%
17 MT-CO2 protein_coding 13,392.5
bar=donor   line=cohort median 		6,023.6 5,810.8 99.2%
18 MT-ND1 protein_coding 13,362.2
bar=donor   line=cohort median 		3,656.3 3,718.2 99.2%
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