GSM6881354

Dataset: gse221521 • Sample: Control group RNA511 • Status: Healthy control
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Quality Control Metrics

18,340,686 Total counts Group median: 12,762,148 • 97.7%ile (↑ High)
27,542 Detected genes Group median: 2,606 • 77.5%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 42.2%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

44.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.13
bar=donor   line=cohort median 		0.17 42.2%
FOXO3 Insulin/IGF-1 Signaling 12.17
bar=donor   line=cohort median 		12.92 41.2%
CETP Lipid Metabolism 0.40
bar=donor   line=cohort median 		0.40 50.0%
SIRT6 Sirtuin Family 3.73
bar=donor   line=cohort median 		3.67 53.1%
SIRT1 Sirtuin Family 2.63
bar=donor   line=cohort median 		3.48 12.7%
SIRT3 Sirtuin Family 0.86
bar=donor   line=cohort median 		1.10 12.7%
IGF1R Insulin/IGF-1 Signaling 0.99
bar=donor   line=cohort median 		4.33 10.1%
KLOTHO Anti-aging 0.11
bar=donor   line=cohort median 		0.06 74.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.09
bar=donor   line=cohort median 		0.07 61.9%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 76.4%
IRS2 Insulin/IGF-1 Signaling 27.54
bar=donor   line=cohort median 		35.28 35.0%
TP53 Tumor Suppression 3.80
bar=donor   line=cohort median 		3.83 49.0%
SHC1 Signal Transduction 9.91
bar=donor   line=cohort median 		8.77 84.2%
ACE Signal Transduction 0.20
bar=donor   line=cohort median 		0.39 16.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 11,237.1 118,093
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,096.3 231,499
3 MT-CO1 ENSG00000198804 protein_coding 6,392.4 180,786
4 MT-CO2 ENSG00000198712 protein_coding 5,345.5 67,060
5 MT-CO3 ENSG00000198938 protein_coding 5,189.3 74,617
6 FTL ENSG00000087086 protein_coding 4,859.8 77,634
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,637.8 81,147
8 MT-ND3 ENSG00000198840 protein_coding 3,956.4 25,107
9 MT-ND4 ENSG00000198886 protein_coding 3,686.0 93,157
10 MT-ND4L ENSG00000212907 protein_coding 3,613.1 19,681

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,060.6
bar=donor   line=cohort median 		1,535.8 1,385.4 78.5%
2 S100A9 protein_coding 11,237.1
bar=donor   line=cohort median 		10,851.3 9,235.1 64.5%
3 IL1B protein_coding 20.6
bar=donor   line=cohort median 		5.6 6.1 96.1%
4 CXCL8 protein_coding 172.7
bar=donor   line=cohort median 		220.4 207.4 37.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.0
bar=donor   line=cohort median 		1.7 2.4 18.4%
6 FCGR3B protein_coding 127.2
bar=donor   line=cohort median 		145.0 129.3 47.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,511.7
bar=donor   line=cohort median 		709.1 706.2 89.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 42.9
bar=donor   line=cohort median 		66.1 56.4 28.8%
9 CD3E protein_coding 23.3
bar=donor   line=cohort median 		37.6 37.7 11.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.1
bar=donor   line=cohort median 		3.1 3.1 22.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 267.7
bar=donor   line=cohort median 		302.3 281.6 44.3%
12 GNLY protein_coding 104.1
bar=donor   line=cohort median 		80.1 70.7 71.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 245.3
bar=donor   line=cohort median 		598.7 582.1 21.0%
14 HBA1 protein_coding 651.8
bar=donor   line=cohort median 		2,133.6 1,960.7 14.2%
15 HBA2 protein_coding 423.5
bar=donor   line=cohort median 		1,142.2 1,083.5 17.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,392.4
bar=donor   line=cohort median 		6,862.1 6,938.4 39.1%
17 MT-CO2 protein_coding 5,345.5
bar=donor   line=cohort median 		6,023.6 5,810.8 36.5%
18 MT-ND1 protein_coding 3,514.3
bar=donor   line=cohort median 		3,656.3 3,718.2 41.7%
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