GSM6881357

Dataset: gse221521 • Sample: DM group RNA519 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,897,345 Total counts Group median: 12,709,871 • 24.6%ile (↓ Low)
25,486 Detected genes Group median: 2,638 • 19.4%ile (↓ Low)
3 Mitochondrial fraction (%) Group median: 6 • 3.9%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

43.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.29
bar=donor   line=cohort median 		0.17 80.1%
FOXO3 Insulin/IGF-1 Signaling 10.10
bar=donor   line=cohort median 		12.92 21.5%
CETP Lipid Metabolism 0.42
bar=donor   line=cohort median 		0.40 55.2%
SIRT6 Sirtuin Family 6.05
bar=donor   line=cohort median 		3.67 99.7%
SIRT1 Sirtuin Family 2.40
bar=donor   line=cohort median 		3.48 5.4%
SIRT3 Sirtuin Family 1.33
bar=donor   line=cohort median 		1.10 84.2%
IGF1R Insulin/IGF-1 Signaling 3.08
bar=donor   line=cohort median 		4.33 35.0%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 30.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 72.3%
IRS2 Insulin/IGF-1 Signaling 18.27
bar=donor   line=cohort median 		35.28 13.7%
TP53 Tumor Suppression 3.45
bar=donor   line=cohort median 		3.83 36.0%
SHC1 Signal Transduction 7.61
bar=donor   line=cohort median 		8.77 12.2%
ACE Signal Transduction 0.32
bar=donor   line=cohort median 		0.39 39.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 23,160.5 157,889
2 MT-RNR2 ENSG00000210082 Mt_rRNA 5,530.2 102,574
3 FTL ENSG00000087086 protein_coding 5,080.6 52,648
4 MT-CO2 ENSG00000198712 protein_coding 4,858.9 39,541
5 MT-RNR1 ENSG00000211459 Mt_rRNA 3,949.2 44,824
6 MT-CO1 ENSG00000198804 protein_coding 3,810.8 69,911
7 S100A8 ENSG00000143546 protein_coding 3,515.1 52,066
8 MT-CO3 ENSG00000198938 protein_coding 3,219.6 30,031
9 RPL13AP5 ENSG00000236552 processed_pseudogene 3,043.6 22,161
10 TMSB10 ENSG00000034510 protein_coding 2,694.2 14,777

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 3,515.1
bar=donor   line=cohort median 		1,568.6 1,385.4 96.6%
2 S100A9 protein_coding 23,160.5
bar=donor   line=cohort median 		10,144.6 9,235.1 97.2%
3 IL1B protein_coding 9.6
bar=donor   line=cohort median 		6.9 6.1 75.4%
4 CXCL8 protein_coding 174.8
bar=donor   line=cohort median 		225.8 207.4 39.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 8.1
bar=donor   line=cohort median 		2.2 2.4 90.4%
6 FCGR3B protein_coding 158.0
bar=donor   line=cohort median 		157.0 129.3 61.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 723.1
bar=donor   line=cohort median 		802.6 706.2 52.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 71.5
bar=donor   line=cohort median 		56.8 56.4 68.1%
9 CD3E protein_coding 29.1
bar=donor   line=cohort median 		36.9 37.7 22.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.3
bar=donor   line=cohort median 		3.2 3.1 26.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 368.6
bar=donor   line=cohort median 		296.3 281.6 71.2%
12 GNLY protein_coding 115.8
bar=donor   line=cohort median 		77.5 70.7 80.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 261.6
bar=donor   line=cohort median 		509.6 582.1 22.5%
14 HBA1 protein_coding 1,063.2
bar=donor   line=cohort median 		1,931.5 1,960.7 30.3%
15 HBA2 protein_coding 736.8
bar=donor   line=cohort median 		1,068.0 1,083.5 34.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 3,810.8
bar=donor   line=cohort median 		7,011.1 6,938.4 3.9%
17 MT-CO2 protein_coding 4,858.9
bar=donor   line=cohort median 		5,968.9 5,810.8 23.6%
18 MT-ND1 protein_coding 1,737.4
bar=donor   line=cohort median 		3,670.4 3,718.2 6.0%
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