GSM6881358

Dataset: gse221521 • Sample: DM group RNA52 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

15,958,809 Total counts Group median: 12,709,871 • 95.1%ile (↑ High)
18,437 Detected genes Group median: 2,638 • 1.8%ile (↓ Low)
10 Mitochondrial fraction (%) Group median: 6 • 94.0%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

37.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.60
bar=donor   line=cohort median 		0.17 98.7%
FOXO3 Insulin/IGF-1 Signaling 2.08
bar=donor   line=cohort median 		12.92 1.8%
CETP Lipid Metabolism 1.24
bar=donor   line=cohort median 		0.40 98.7%
SIRT6 Sirtuin Family 0.78
bar=donor   line=cohort median 		3.67 0.8%
SIRT1 Sirtuin Family 5.53
bar=donor   line=cohort median 		3.48 94.6%
SIRT3 Sirtuin Family 1.42
bar=donor   line=cohort median 		1.10 89.4%
IGF1R Insulin/IGF-1 Signaling 2.24
bar=donor   line=cohort median 		4.33 22.0%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 3.17
bar=donor   line=cohort median 		35.28 0.3%
TP53 Tumor Suppression 3.80
bar=donor   line=cohort median 		3.83 48.5%
SHC1 Signal Transduction 5.40
bar=donor   line=cohort median 		8.77 1.8%
ACE Signal Transduction 0.21
bar=donor   line=cohort median 		0.39 18.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 35,739.2 889,183
2 MT-CO1 ENSG00000198804 protein_coding 13,077.4 321,816
3 TMSB4XP8 ENSG00000187653 processed_pseudogene 8,761.4 18,876
4 MT-RNR1 ENSG00000211459 Mt_rRNA 7,270.5 110,691
5 MT-CO3 ENSG00000198938 protein_coding 5,485.3 68,630
6 AC116533.1 ENSG00000244398 processed_pseudogene 5,313.5 27,220
7 RPS28P7 ENSG00000227097 processed_pseudogene 5,035.6 16,876
8 EEF1A1P5 ENSG00000196205 processed_pseudogene 4,481.0 99,330
9 MT-CO2 ENSG00000198712 protein_coding 3,996.9 43,630
10 AC113935.1 ENSG00000226084 processed_pseudogene 3,759.5 33,298

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 106.1
bar=donor   line=cohort median 		1,568.6 1,385.4 0.8%
2 S100A9 protein_coding 353.8
bar=donor   line=cohort median 		10,144.6 9,235.1 0.3%
3 IL1B protein_coding 0.5
bar=donor   line=cohort median 		6.9 6.1 2.3%
4 CXCL8 protein_coding 13.0
bar=donor   line=cohort median 		225.8 207.4 1.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.4
bar=donor   line=cohort median 		2.2 2.4 3.9%
6 FCGR3B protein_coding 13.5
bar=donor   line=cohort median 		157.0 129.3 2.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 312.8
bar=donor   line=cohort median 		802.6 706.2 12.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 129.7
bar=donor   line=cohort median 		56.8 56.4 96.1%
9 CD3E protein_coding 66.2
bar=donor   line=cohort median 		36.9 37.7 89.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 33.9
bar=donor   line=cohort median 		3.2 3.1 98.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 323.6
bar=donor   line=cohort median 		296.3 281.6 63.0%
12 GNLY protein_coding 117.6
bar=donor   line=cohort median 		77.5 70.7 82.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 691.9
bar=donor   line=cohort median 		509.6 582.1 57.8%
14 HBA1 protein_coding 1,784.5
bar=donor   line=cohort median 		1,931.5 1,960.7 46.4%
15 HBA2 protein_coding 535.0
bar=donor   line=cohort median 		1,068.0 1,083.5 24.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 13,077.4
bar=donor   line=cohort median 		7,011.1 6,938.4 97.7%
17 MT-CO2 protein_coding 3,996.9
bar=donor   line=cohort median 		5,968.9 5,810.8 11.7%
18 MT-ND1 protein_coding 1,671.0
bar=donor   line=cohort median 		3,670.4 3,718.2 3.9%
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