GSM6881359

Dataset: gse221521 • Sample: DM group RNA521 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

17,687,166 Total counts Group median: 12,709,871 • 96.6%ile (↑ High)
28,429 Detected genes Group median: 2,638 • 92.5%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 30.8%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

51.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.28
bar=donor   line=cohort median 		0.17 78.0%
FOXO3 Insulin/IGF-1 Signaling 12.85
bar=donor   line=cohort median 		12.92 46.9%
CETP Lipid Metabolism 0.63
bar=donor   line=cohort median 		0.40 84.7%
SIRT6 Sirtuin Family 3.32
bar=donor   line=cohort median 		3.67 29.3%
SIRT1 Sirtuin Family 3.47
bar=donor   line=cohort median 		3.48 48.5%
SIRT3 Sirtuin Family 1.03
bar=donor   line=cohort median 		1.10 37.1%
IGF1R Insulin/IGF-1 Signaling 2.39
bar=donor   line=cohort median 		4.33 25.1%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 62.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.06
bar=donor   line=cohort median 		0.07 46.4%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 59.3%
IRS2 Insulin/IGF-1 Signaling 25.45
bar=donor   line=cohort median 		35.28 30.3%
TP53 Tumor Suppression 3.49
bar=donor   line=cohort median 		3.83 37.6%
SHC1 Signal Transduction 10.00
bar=donor   line=cohort median 		8.77 85.2%
ACE Signal Transduction 0.36
bar=donor   line=cohort median 		0.39 46.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 6,324.4 64,096
2 MT-RNR2 ENSG00000210082 Mt_rRNA 6,045.8 166,710
3 MT-CO1 ENSG00000198804 protein_coding 5,628.1 153,498
4 MT-CO2 ENSG00000198712 protein_coding 5,368.2 64,945
5 MT-ND3 ENSG00000198840 protein_coding 4,583.3 28,049
6 MT-ATP6 ENSG00000198899 protein_coding 4,438.2 53,458
7 MT-ND4L ENSG00000212907 protein_coding 3,982.6 20,921
8 MT-CO3 ENSG00000198938 protein_coding 3,821.5 52,992
9 MT-ND4 ENSG00000198886 protein_coding 3,613.8 88,080
10 AC005912.1 ENSG00000227081 processed_pseudogene 3,493.2 15,755

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,016.8
bar=donor   line=cohort median 		1,568.6 1,385.4 22.5%
2 S100A9 protein_coding 6,324.4
bar=donor   line=cohort median 		10,144.6 9,235.1 26.2%
3 IL1B protein_coding 7.2
bar=donor   line=cohort median 		6.9 6.1 60.9%
4 CXCL8 protein_coding 82.2
bar=donor   line=cohort median 		225.8 207.4 14.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.2
bar=donor   line=cohort median 		2.2 2.4 23.1%
6 FCGR3B protein_coding 104.3
bar=donor   line=cohort median 		157.0 129.3 36.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,076.2
bar=donor   line=cohort median 		802.6 706.2 76.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 70.5
bar=donor   line=cohort median 		56.8 56.4 67.6%
9 CD3E protein_coding 44.4
bar=donor   line=cohort median 		36.9 37.7 67.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.0
bar=donor   line=cohort median 		3.2 3.1 71.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 505.8
bar=donor   line=cohort median 		296.3 281.6 88.9%
12 GNLY protein_coding 140.3
bar=donor   line=cohort median 		77.5 70.7 88.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 742.6
bar=donor   line=cohort median 		509.6 582.1 60.4%
14 HBA1 protein_coding 2,114.3
bar=donor   line=cohort median 		1,931.5 1,960.7 53.6%
15 HBA2 protein_coding 1,201.7
bar=donor   line=cohort median 		1,068.0 1,083.5 56.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,628.1
bar=donor   line=cohort median 		7,011.1 6,938.4 24.6%
17 MT-CO2 protein_coding 5,368.2
bar=donor   line=cohort median 		5,968.9 5,810.8 38.6%
18 MT-ND1 protein_coding 2,825.3
bar=donor   line=cohort median 		3,670.4 3,718.2 20.5%
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