GSM6881360

Dataset: gse221521 • Sample: DM group RNA528 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,492,262 Total counts Group median: 12,709,871 • 16.3%ile (↓ Low)
26,203 Detected genes Group median: 2,638 • 40.2%ile (≈ Median)
4 Mitochondrial fraction (%) Group median: 6 • 5.4%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

57.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.17 64.0%
FOXO3 Insulin/IGF-1 Signaling 18.27
bar=donor   line=cohort median 		12.92 87.3%
CETP Lipid Metabolism 0.29
bar=donor   line=cohort median 		0.40 25.7%
SIRT6 Sirtuin Family 3.41
bar=donor   line=cohort median 		3.67 35.0%
SIRT1 Sirtuin Family 3.47
bar=donor   line=cohort median 		3.48 49.0%
SIRT3 Sirtuin Family 1.03
bar=donor   line=cohort median 		1.10 37.6%
IGF1R Insulin/IGF-1 Signaling 7.92
bar=donor   line=cohort median 		4.33 95.1%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 67.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.07
bar=donor   line=cohort median 		0.07 50.5%
TERT Telomere Maintenance 0.05
bar=donor   line=cohort median 		0.01 87.8%
IRS2 Insulin/IGF-1 Signaling 111.72
bar=donor   line=cohort median 		35.28 98.2%
TP53 Tumor Suppression 2.02
bar=donor   line=cohort median 		3.83 2.3%
SHC1 Signal Transduction 9.39
bar=donor   line=cohort median 		8.77 70.2%
ACE Signal Transduction 0.31
bar=donor   line=cohort median 		0.39 38.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 16,761.9 110,378
2 FTL ENSG00000087086 protein_coding 5,304.9 53,101
3 MT-RNR2 ENSG00000210082 Mt_rRNA 5,044.9 90,386
4 MT-CO1 ENSG00000198804 protein_coding 3,638.9 64,485
5 MT-ATP6 ENSG00000198899 protein_coding 3,579.2 28,012
6 MT-CO2 ENSG00000198712 protein_coding 3,450.5 27,123
7 MT-CO3 ENSG00000198938 protein_coding 2,850.0 25,678
8 H3P6 ENSG00000235655 processed_pseudogene 2,710.4 12,802
9 MT-ND3 ENSG00000198840 protein_coding 2,612.2 10,387
10 MT-ATP8 ENSG00000228253 protein_coding 2,596.2 6,176

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,296.7
bar=donor   line=cohort median 		1,568.6 1,385.4 82.6%
2 S100A9 protein_coding 16,761.9
bar=donor   line=cohort median 		10,144.6 9,235.1 88.9%
3 IL1B protein_coding 7.3
bar=donor   line=cohort median 		6.9 6.1 62.4%
4 CXCL8 protein_coding 194.8
bar=donor   line=cohort median 		225.8 207.4 43.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 5.8
bar=donor   line=cohort median 		2.2 2.4 83.2%
6 FCGR3B protein_coding 86.4
bar=donor   line=cohort median 		157.0 129.3 27.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 646.1
bar=donor   line=cohort median 		802.6 706.2 42.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 35.6
bar=donor   line=cohort median 		56.8 56.4 16.3%
9 CD3E protein_coding 25.5
bar=donor   line=cohort median 		36.9 37.7 15.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.0
bar=donor   line=cohort median 		3.2 3.1 17.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 192.5
bar=donor   line=cohort median 		296.3 281.6 23.1%
12 GNLY protein_coding 38.5
bar=donor   line=cohort median 		77.5 70.7 14.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 394.8
bar=donor   line=cohort median 		509.6 582.1 33.4%
14 HBA1 protein_coding 1,689.2
bar=donor   line=cohort median 		1,931.5 1,960.7 42.7%
15 HBA2 protein_coding 818.2
bar=donor   line=cohort median 		1,068.0 1,083.5 40.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 3,638.9
bar=donor   line=cohort median 		7,011.1 6,938.4 2.8%
17 MT-CO2 protein_coding 3,450.5
bar=donor   line=cohort median 		5,968.9 5,810.8 5.4%
18 MT-ND1 protein_coding 1,875.5
bar=donor   line=cohort median 		3,670.4 3,718.2 6.5%
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