GSM6881362

Dataset: gse221521 • Sample: DM group RNA53 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

15,845,584 Total counts Group median: 12,709,871 • 94.6%ile (↑ High)
26,136 Detected genes Group median: 2,638 • 37.6%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 37.6%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

45.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.18
bar=donor   line=cohort median 		0.17 56.2%
FOXO3 Insulin/IGF-1 Signaling 18.07
bar=donor   line=cohort median 		12.92 85.8%
CETP Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.40 9.1%
SIRT6 Sirtuin Family 4.04
bar=donor   line=cohort median 		3.67 68.1%
SIRT1 Sirtuin Family 3.53
bar=donor   line=cohort median 		3.48 54.7%
SIRT3 Sirtuin Family 1.08
bar=donor   line=cohort median 		1.10 46.9%
IGF1R Insulin/IGF-1 Signaling 3.01
bar=donor   line=cohort median 		4.33 33.9%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 31.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 38.1%
IRS2 Insulin/IGF-1 Signaling 108.09
bar=donor   line=cohort median 		35.28 97.7%
TP53 Tumor Suppression 3.42
bar=donor   line=cohort median 		3.83 34.5%
SHC1 Signal Transduction 8.93
bar=donor   line=cohort median 		8.77 56.2%
ACE Signal Transduction 0.19
bar=donor   line=cohort median 		0.39 13.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 8,234.8 74,768
2 MT-RNR2 ENSG00000210082 Mt_rRNA 6,964.9 172,055
3 MT-CO1 ENSG00000198804 protein_coding 6,903.3 168,674
4 MT-CO3 ENSG00000198938 protein_coding 6,142.8 76,312
5 MT-CO2 ENSG00000198712 protein_coding 5,569.6 60,365
6 FTL ENSG00000087086 protein_coding 5,012.7 69,183
7 MT-ND1 ENSG00000198888 protein_coding 4,321.7 65,467
8 MT-RNR1 ENSG00000211459 Mt_rRNA 4,211.0 63,656
9 MT-ND4 ENSG00000198886 protein_coding 3,772.8 82,379
10 MT-ND2 ENSG00000198763 protein_coding 3,147.0 51,961

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 774.7
bar=donor   line=cohort median 		1,568.6 1,385.4 13.2%
2 S100A9 protein_coding 8,234.8
bar=donor   line=cohort median 		10,144.6 9,235.1 41.7%
3 IL1B protein_coding 3.4
bar=donor   line=cohort median 		6.9 6.1 20.5%
4 CXCL8 protein_coding 137.8
bar=donor   line=cohort median 		225.8 207.4 28.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 8.8
bar=donor   line=cohort median 		2.2 2.4 92.5%
6 FCGR3B protein_coding 69.2
bar=donor   line=cohort median 		157.0 129.3 17.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 701.2
bar=donor   line=cohort median 		802.6 706.2 48.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 26.1
bar=donor   line=cohort median 		56.8 56.4 4.4%
9 CD3E protein_coding 35.1
bar=donor   line=cohort median 		36.9 37.7 43.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.3
bar=donor   line=cohort median 		3.2 3.1 6.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 497.8
bar=donor   line=cohort median 		296.3 281.6 87.8%
12 GNLY protein_coding 97.0
bar=donor   line=cohort median 		77.5 70.7 67.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 968.3
bar=donor   line=cohort median 		509.6 582.1 70.7%
14 HBA1 protein_coding 1,902.3
bar=donor   line=cohort median 		1,931.5 1,960.7 47.9%
15 HBA2 protein_coding 2,061.6
bar=donor   line=cohort median 		1,068.0 1,083.5 71.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,903.3
bar=donor   line=cohort median 		7,011.1 6,938.4 48.4%
17 MT-CO2 protein_coding 5,569.6
bar=donor   line=cohort median 		5,968.9 5,810.8 41.2%
18 MT-ND1 protein_coding 4,321.7
bar=donor   line=cohort median 		3,670.4 3,718.2 68.7%
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