GSM6881363

Dataset: gse221521 • Sample: DR group RNA535 • Status: Diabetic retinopathy
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Quality Control Metrics

12,548,551 Total counts Group median: 12,498,211 • 48.4%ile (≈ Median)
26,925 Detected genes Group median: 27,368 • 63.0%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 47.9%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

48.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.36
bar=donor   line=cohort median 		0.17 91.5%
FOXO3 Insulin/IGF-1 Signaling 8.33
bar=donor   line=cohort median 		12.92 14.8%
CETP Lipid Metabolism 0.32
bar=donor   line=cohort median 		0.40 31.9%
SIRT6 Sirtuin Family 4.74
bar=donor   line=cohort median 		3.67 87.3%
SIRT1 Sirtuin Family 3.24
bar=donor   line=cohort median 		3.48 37.6%
SIRT3 Sirtuin Family 1.17
bar=donor   line=cohort median 		1.10 61.9%
IGF1R Insulin/IGF-1 Signaling 1.66
bar=donor   line=cohort median 		4.33 13.7%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 45.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.45
bar=donor   line=cohort median 		0.07 99.2%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 58.3%
IRS2 Insulin/IGF-1 Signaling 10.34
bar=donor   line=cohort median 		35.28 7.5%
TP53 Tumor Suppression 2.20
bar=donor   line=cohort median 		3.83 3.4%
SHC1 Signal Transduction 9.41
bar=donor   line=cohort median 		8.77 71.2%
ACE Signal Transduction 0.44
bar=donor   line=cohort median 		0.39 58.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,980.6 107,715
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,553.8 167,339
3 MT-CO2 ENSG00000198712 protein_coding 7,035.9 60,391
4 AC005912.1 ENSG00000227081 processed_pseudogene 5,980.2 19,136
5 MT-CO1 ENSG00000198804 protein_coding 5,954.4 115,217
6 MT-CO3 ENSG00000198938 protein_coding 5,644.1 55,527
7 FTL ENSG00000087086 protein_coding 4,736.0 51,764
8 MT-ND3 ENSG00000198840 protein_coding 4,716.2 20,477
9 MT-RNR1 ENSG00000211459 Mt_rRNA 4,488.9 53,738
10 MT-ND4 ENSG00000198886 protein_coding 3,965.0 68,563

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,633.9
bar=donor   line=cohort median 		1,223.7 1,385.4 90.4%
2 S100A9 protein_coding 14,980.6
bar=donor   line=cohort median 		7,732.1 9,235.1 84.7%
3 IL1B protein_coding 23.2
bar=donor   line=cohort median 		4.9 6.1 97.2%
4 CXCL8 protein_coding 292.8
bar=donor   line=cohort median 		197.4 207.4 64.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 5.1
bar=donor   line=cohort median 		2.9 2.4 81.6%
6 FCGR3B protein_coding 99.4
bar=donor   line=cohort median 		108.9 129.3 33.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 853.5
bar=donor   line=cohort median 		581.4 706.2 62.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 82.8
bar=donor   line=cohort median 		51.6 56.4 78.0%
9 CD3E protein_coding 44.8
bar=donor   line=cohort median 		38.1 37.7 68.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 6.1
bar=donor   line=cohort median 		3.0 3.1 89.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 322.5
bar=donor   line=cohort median 		252.2 281.6 62.4%
12 GNLY protein_coding 94.9
bar=donor   line=cohort median 		58.9 70.7 65.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 838.9
bar=donor   line=cohort median 		585.0 582.1 66.6%
14 HBA1 protein_coding 1,752.3
bar=donor   line=cohort median 		1,960.4 1,960.7 44.8%
15 HBA2 protein_coding 1,038.9
bar=donor   line=cohort median 		1,080.5 1,083.5 45.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,954.4
bar=donor   line=cohort median 		6,740.9 6,938.4 29.8%
17 MT-CO2 protein_coding 7,035.9
bar=donor   line=cohort median 		5,693.7 5,810.8 69.2%
18 MT-ND1 protein_coding 3,484.9
bar=donor   line=cohort median 		3,876.8 3,718.2 40.7%
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