GSM6881365

Dataset: gse221521 • Sample: DM group RNA58 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,710,457 Total counts Group median: 12,709,871 • 21.0%ile (↓ Low)
25,748 Detected genes Group median: 2,638 • 24.6%ile (↓ Low)
5 Mitochondrial fraction (%) Group median: 6 • 28.8%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

57.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.14
bar=donor   line=cohort median 		0.17 43.8%
FOXO3 Insulin/IGF-1 Signaling 9.23
bar=donor   line=cohort median 		12.92 17.4%
CETP Lipid Metabolism 0.71
bar=donor   line=cohort median 		0.40 90.4%
SIRT6 Sirtuin Family 3.83
bar=donor   line=cohort median 		3.67 57.8%
SIRT1 Sirtuin Family 4.00
bar=donor   line=cohort median 		3.48 70.2%
SIRT3 Sirtuin Family 1.28
bar=donor   line=cohort median 		1.10 75.4%
IGF1R Insulin/IGF-1 Signaling 5.64
bar=donor   line=cohort median 		4.33 73.3%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 32.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.12
bar=donor   line=cohort median 		0.07 78.0%
TERT Telomere Maintenance 0.04
bar=donor   line=cohort median 		0.01 83.2%
IRS2 Insulin/IGF-1 Signaling 53.00
bar=donor   line=cohort median 		35.28 75.9%
TP53 Tumor Suppression 3.20
bar=donor   line=cohort median 		3.83 27.7%
SHC1 Signal Transduction 8.97
bar=donor   line=cohort median 		8.77 57.8%
ACE Signal Transduction 0.25
bar=donor   line=cohort median 		0.39 28.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 9,666.5 64,863
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,783.4 142,099
3 MT-CO1 ENSG00000198804 protein_coding 5,773.3 104,251
4 MT-RNR1 ENSG00000211459 Mt_rRNA 5,716.3 63,861
5 MT-CO2 ENSG00000198712 protein_coding 4,861.5 38,940
6 MT-CO3 ENSG00000198938 protein_coding 4,523.9 41,534
7 FTL ENSG00000087086 protein_coding 4,304.7 43,907
8 MT-ND1 ENSG00000198888 protein_coding 3,759.1 42,084
9 HBA2 ENSG00000188536 protein_coding 3,660.9 72,365
10 HBA1 ENSG00000206172 protein_coding 3,449.9 69,488

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,137.9
bar=donor   line=cohort median 		1,568.6 1,385.4 33.4%
2 S100A9 protein_coding 9,666.5
bar=donor   line=cohort median 		10,144.6 9,235.1 53.6%
3 IL1B protein_coding 8.3
bar=donor   line=cohort median 		6.9 6.1 68.7%
4 CXCL8 protein_coding 184.6
bar=donor   line=cohort median 		225.8 207.4 42.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 4.2
bar=donor   line=cohort median 		2.2 2.4 78.5%
6 FCGR3B protein_coding 253.9
bar=donor   line=cohort median 		157.0 129.3 89.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 564.5
bar=donor   line=cohort median 		802.6 706.2 34.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 41.6
bar=donor   line=cohort median 		56.8 56.4 25.6%
9 CD3E protein_coding 43.6
bar=donor   line=cohort median 		36.9 37.7 66.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.0
bar=donor   line=cohort median 		3.2 3.1 68.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 239.0
bar=donor   line=cohort median 		296.3 281.6 35.5%
12 GNLY protein_coding 46.7
bar=donor   line=cohort median 		77.5 70.7 23.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 2,275.8
bar=donor   line=cohort median 		509.6 582.1 93.5%
14 HBA1 protein_coding 3,449.9
bar=donor   line=cohort median 		1,931.5 1,960.7 67.6%
15 HBA2 protein_coding 3,660.9
bar=donor   line=cohort median 		1,068.0 1,083.5 85.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,773.3
bar=donor   line=cohort median 		7,011.1 6,938.4 26.7%
17 MT-CO2 protein_coding 4,861.5
bar=donor   line=cohort median 		5,968.9 5,810.8 24.1%
18 MT-ND1 protein_coding 3,759.1
bar=donor   line=cohort median 		3,670.4 3,718.2 51.6%
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