GSM6881366

Dataset: gse221521 • Sample: DM group RNA6 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,244,065 Total counts Group median: 12,709,871 • 35.0%ile (≈ Median)
27,372 Detected genes Group median: 2,638 • 75.6%ile (↑ High)
7 Mitochondrial fraction (%) Group median: 6 • 72.3%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

40.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 12.59
bar=donor   line=cohort median 		12.92 44.8%
CETP Lipid Metabolism 0.25
bar=donor   line=cohort median 		0.40 17.9%
SIRT6 Sirtuin Family 2.74
bar=donor   line=cohort median 		3.67 11.1%
SIRT1 Sirtuin Family 4.65
bar=donor   line=cohort median 		3.48 83.7%
SIRT3 Sirtuin Family 1.08
bar=donor   line=cohort median 		1.10 46.4%
IGF1R Insulin/IGF-1 Signaling 2.32
bar=donor   line=cohort median 		4.33 23.1%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 16.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.08
bar=donor   line=cohort median 		0.07 58.3%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 71.2%
IRS2 Insulin/IGF-1 Signaling 28.74
bar=donor   line=cohort median 		35.28 38.6%
TP53 Tumor Suppression 3.63
bar=donor   line=cohort median 		3.83 43.8%
SHC1 Signal Transduction 7.86
bar=donor   line=cohort median 		8.77 16.8%
ACE Signal Transduction 0.60
bar=donor   line=cohort median 		0.39 81.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 9,433.4 180,069
2 MT-CO1 ENSG00000198804 protein_coding 8,435.8 159,271
3 MT-CO2 ENSG00000198712 protein_coding 8,250.1 69,094
4 S100A9 ENSG00000163220 protein_coding 7,490.0 52,549
5 MT-CO3 ENSG00000198938 protein_coding 6,471.9 62,126
6 TMSB4XP8 ENSG00000187653 processed_pseudogene 6,191.4 10,234
7 MT-RNR1 ENSG00000211459 Mt_rRNA 5,271.5 61,576
8 MT-ND3 ENSG00000198840 protein_coding 5,002.3 21,192
9 MT-ND1 ENSG00000198888 protein_coding 4,790.7 56,077
10 MT-ND4 ENSG00000198886 protein_coding 4,790.2 80,821

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,270.9
bar=donor   line=cohort median 		1,568.6 1,385.4 42.7%
2 S100A9 protein_coding 7,490.0
bar=donor   line=cohort median 		10,144.6 9,235.1 36.5%
3 IL1B protein_coding 4.3
bar=donor   line=cohort median 		6.9 6.1 29.8%
4 CXCL8 protein_coding 158.1
bar=donor   line=cohort median 		225.8 207.4 33.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.0
bar=donor   line=cohort median 		2.2 2.4 44.8%
6 FCGR3B protein_coding 172.5
bar=donor   line=cohort median 		157.0 129.3 66.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 486.3
bar=donor   line=cohort median 		802.6 706.2 26.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 65.1
bar=donor   line=cohort median 		56.8 56.4 63.0%
9 CD3E protein_coding 43.9
bar=donor   line=cohort median 		36.9 37.7 67.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.6
bar=donor   line=cohort median 		3.2 3.1 77.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 245.1
bar=donor   line=cohort median 		296.3 281.6 37.6%
12 GNLY protein_coding 45.2
bar=donor   line=cohort median 		77.5 70.7 21.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 411.8
bar=donor   line=cohort median 		509.6 582.1 35.5%
14 HBA1 protein_coding 1,178.6
bar=donor   line=cohort median 		1,931.5 1,960.7 32.9%
15 HBA2 protein_coding 886.9
bar=donor   line=cohort median 		1,068.0 1,083.5 42.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,435.8
bar=donor   line=cohort median 		7,011.1 6,938.4 74.4%
17 MT-CO2 protein_coding 8,250.1
bar=donor   line=cohort median 		5,968.9 5,810.8 82.6%
18 MT-ND1 protein_coding 4,790.7
bar=donor   line=cohort median 		3,670.4 3,718.2 77.5%
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