GSM6881367

Dataset: gse221521 • Sample: DM group RNA60 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,984,132 Total counts Group median: 12,709,871 • 25.1%ile (≈ Median)
26,477 Detected genes Group median: 2,638 • 51.0%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 54.7%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

41.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.09
bar=donor   line=cohort median 		0.17 28.2%
FOXO3 Insulin/IGF-1 Signaling 11.62
bar=donor   line=cohort median 		12.92 37.6%
CETP Lipid Metabolism 0.30
bar=donor   line=cohort median 		0.40 27.7%
SIRT6 Sirtuin Family 3.32
bar=donor   line=cohort median 		3.67 29.8%
SIRT1 Sirtuin Family 3.20
bar=donor   line=cohort median 		3.48 36.0%
SIRT3 Sirtuin Family 1.20
bar=donor   line=cohort median 		1.10 63.0%
IGF1R Insulin/IGF-1 Signaling 1.71
bar=donor   line=cohort median 		4.33 15.3%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 30.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 33.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 48.99
bar=donor   line=cohort median 		35.28 70.2%
TP53 Tumor Suppression 3.86
bar=donor   line=cohort median 		3.83 50.5%
SHC1 Signal Transduction 8.37
bar=donor   line=cohort median 		8.77 36.0%
ACE Signal Transduction 0.80
bar=donor   line=cohort median 		0.39 91.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 9,838.0 183,805
2 S100A9 ENSG00000163220 protein_coding 7,549.2 51,840
3 MT-CO1 ENSG00000198804 protein_coding 6,673.1 123,316
4 MT-RNR1 ENSG00000211459 Mt_rRNA 6,081.2 69,526
5 MT-CO2 ENSG00000198712 protein_coding 5,760.3 47,218
6 MT-CO3 ENSG00000198938 protein_coding 5,292.1 49,722
7 MT-ND1 ENSG00000198888 protein_coding 4,667.0 53,469
8 FTL ENSG00000087086 protein_coding 4,572.7 47,731
9 MT-ND4 ENSG00000198886 protein_coding 3,765.3 62,181
10 MT-ND2 ENSG00000198763 protein_coding 3,330.3 41,587

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 983.1
bar=donor   line=cohort median 		1,568.6 1,385.4 21.5%
2 S100A9 protein_coding 7,549.2
bar=donor   line=cohort median 		10,144.6 9,235.1 37.0%
3 IL1B protein_coding 6.9
bar=donor   line=cohort median 		6.9 6.1 60.4%
4 CXCL8 protein_coding 268.5
bar=donor   line=cohort median 		225.8 207.4 61.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.2
bar=donor   line=cohort median 		2.2 2.4 1.3%
6 FCGR3B protein_coding 54.3
bar=donor   line=cohort median 		157.0 129.3 11.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 216.1
bar=donor   line=cohort median 		802.6 706.2 4.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 64.4
bar=donor   line=cohort median 		56.8 56.4 61.9%
9 CD3E protein_coding 58.7
bar=donor   line=cohort median 		36.9 37.7 86.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.1
bar=donor   line=cohort median 		3.2 3.1 49.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 318.1
bar=donor   line=cohort median 		296.3 281.6 60.9%
12 GNLY protein_coding 127.6
bar=donor   line=cohort median 		77.5 70.7 85.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 848.3
bar=donor   line=cohort median 		509.6 582.1 67.1%
14 HBA1 protein_coding 1,234.7
bar=donor   line=cohort median 		1,931.5 1,960.7 35.0%
15 HBA2 protein_coding 1,211.8
bar=donor   line=cohort median 		1,068.0 1,083.5 56.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,673.1
bar=donor   line=cohort median 		7,011.1 6,938.4 43.3%
17 MT-CO2 protein_coding 5,760.3
bar=donor   line=cohort median 		5,968.9 5,810.8 49.0%
18 MT-ND1 protein_coding 4,667.0
bar=donor   line=cohort median 		3,670.4 3,718.2 75.4%
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