GSM6881369

Dataset: gse221521 • Sample: DM group RNA62 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,770,170 Total counts Group median: 12,709,871 • 22.0%ile (↓ Low)
24,619 Detected genes Group median: 2,638 • 9.1%ile (↓ Low)
6 Mitochondrial fraction (%) Group median: 6 • 38.6%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

47.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.16
bar=donor   line=cohort median 		0.17 46.9%
FOXO3 Insulin/IGF-1 Signaling 17.99
bar=donor   line=cohort median 		12.92 85.2%
CETP Lipid Metabolism 0.50
bar=donor   line=cohort median 		0.40 69.2%
SIRT6 Sirtuin Family 4.27
bar=donor   line=cohort median 		3.67 76.4%
SIRT1 Sirtuin Family 3.83
bar=donor   line=cohort median 		3.48 66.1%
SIRT3 Sirtuin Family 0.89
bar=donor   line=cohort median 		1.10 17.9%
IGF1R Insulin/IGF-1 Signaling 8.82
bar=donor   line=cohort median 		4.33 96.6%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 31.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 33.9%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 93.34
bar=donor   line=cohort median 		35.28 96.6%
TP53 Tumor Suppression 2.54
bar=donor   line=cohort median 		3.83 11.7%
SHC1 Signal Transduction 7.26
bar=donor   line=cohort median 		8.77 7.5%
ACE Signal Transduction 0.12
bar=donor   line=cohort median 		0.39 2.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,850.3 100,155
2 MT-RNR2 ENSG00000210082 Mt_rRNA 11,185.3 205,247
3 FTL ENSG00000087086 protein_coding 6,815.4 69,870
4 MT-RNR1 ENSG00000211459 Mt_rRNA 6,460.5 72,543
5 MT-CO2 ENSG00000198712 protein_coding 5,012.9 40,358
6 MT-CO1 ENSG00000198804 protein_coding 4,755.1 86,304
7 MT-CO3 ENSG00000198938 protein_coding 4,498.2 41,509
8 MT-ND1 ENSG00000198888 protein_coding 4,079.7 45,906
9 HBA2 ENSG00000188536 protein_coding 4,006.9 79,609
10 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,939.0 6,259

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,020.1
bar=donor   line=cohort median 		1,568.6 1,385.4 23.6%
2 S100A9 protein_coding 14,850.3
bar=donor   line=cohort median 		10,144.6 9,235.1 82.6%
3 IL1B protein_coding 5.1
bar=donor   line=cohort median 		6.9 6.1 41.7%
4 CXCL8 protein_coding 575.6
bar=donor   line=cohort median 		225.8 207.4 92.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.2
bar=donor   line=cohort median 		2.2 2.4 24.1%
6 FCGR3B protein_coding 381.0
bar=donor   line=cohort median 		157.0 129.3 95.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,205.9
bar=donor   line=cohort median 		802.6 706.2 83.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 40.3
bar=donor   line=cohort median 		56.8 56.4 23.6%
9 CD3E protein_coding 36.6
bar=donor   line=cohort median 		36.9 37.7 45.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.1
bar=donor   line=cohort median 		3.2 3.1 4.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 297.1
bar=donor   line=cohort median 		296.3 281.6 54.7%
12 GNLY protein_coding 84.2
bar=donor   line=cohort median 		77.5 70.7 60.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,318.0
bar=donor   line=cohort median 		509.6 582.1 81.1%
14 HBA1 protein_coding 3,886.8
bar=donor   line=cohort median 		1,931.5 1,960.7 72.8%
15 HBA2 protein_coding 4,006.9
bar=donor   line=cohort median 		1,068.0 1,083.5 87.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,755.1
bar=donor   line=cohort median 		7,011.1 6,938.4 10.1%
17 MT-CO2 protein_coding 5,012.9
bar=donor   line=cohort median 		5,968.9 5,810.8 27.7%
18 MT-ND1 protein_coding 4,079.7
bar=donor   line=cohort median 		3,670.4 3,718.2 60.9%
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