GSM6881370

Dataset: gse221521 • Sample: DM group RNA63 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,487,974 Total counts Group median: 12,709,871 • 77.5%ile (↑ High)
24,529 Detected genes Group median: 2,638 • 8.0%ile (↓ Low)
8 Mitochondrial fraction (%) Group median: 6 • 79.5%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

39.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.04
bar=donor   line=cohort median 		0.17 14.8%
FOXO3 Insulin/IGF-1 Signaling 14.10
bar=donor   line=cohort median 		12.92 57.8%
CETP Lipid Metabolism 0.10
bar=donor   line=cohort median 		0.40 1.8%
SIRT6 Sirtuin Family 3.54
bar=donor   line=cohort median 		3.67 42.2%
SIRT1 Sirtuin Family 3.18
bar=donor   line=cohort median 		3.48 35.5%
SIRT3 Sirtuin Family 1.33
bar=donor   line=cohort median 		1.10 83.2%
IGF1R Insulin/IGF-1 Signaling 9.76
bar=donor   line=cohort median 		4.33 97.2%
KLOTHO Anti-aging 0.07
bar=donor   line=cohort median 		0.06 52.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.06
bar=donor   line=cohort median 		0.07 46.9%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 40.69
bar=donor   line=cohort median 		35.28 58.3%
TP53 Tumor Suppression 2.30
bar=donor   line=cohort median 		3.83 5.4%
SHC1 Signal Transduction 7.73
bar=donor   line=cohort median 		8.77 13.7%
ACE Signal Transduction 0.18
bar=donor   line=cohort median 		0.39 11.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 11,650.7 244,989
2 HBA1 ENSG00000206172 protein_coding 10,329.5 239,637
3 S100A9 ENSG00000163220 protein_coding 8,275.7 63,960
4 MT-RNR1 ENSG00000211459 Mt_rRNA 7,818.4 100,604
5 MT-CO2 ENSG00000198712 protein_coding 7,691.2 70,957
6 HBA2 ENSG00000188536 protein_coding 7,467.9 170,027
7 MT-ATP6 ENSG00000198899 protein_coding 7,332.5 67,351
8 MT-CO1 ENSG00000198804 protein_coding 7,014.5 145,890
9 MT-CO3 ENSG00000198938 protein_coding 5,998.4 63,431
10 MT-ND1 ENSG00000198888 protein_coding 5,923.3 76,378

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,696.0
bar=donor   line=cohort median 		1,568.6 1,385.4 61.9%
2 S100A9 protein_coding 8,275.7
bar=donor   line=cohort median 		10,144.6 9,235.1 43.3%
3 IL1B protein_coding 9.6
bar=donor   line=cohort median 		6.9 6.1 75.9%
4 CXCL8 protein_coding 402.3
bar=donor   line=cohort median 		225.8 207.4 81.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.8
bar=donor   line=cohort median 		2.2 2.4 40.2%
6 FCGR3B protein_coding 236.1
bar=donor   line=cohort median 		157.0 129.3 86.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 251.5
bar=donor   line=cohort median 		802.6 706.2 6.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 57.6
bar=donor   line=cohort median 		56.8 56.4 52.1%
9 CD3E protein_coding 56.2
bar=donor   line=cohort median 		36.9 37.7 84.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.0
bar=donor   line=cohort median 		3.2 3.1 19.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 278.2
bar=donor   line=cohort median 		296.3 281.6 48.4%
12 GNLY protein_coding 76.3
bar=donor   line=cohort median 		77.5 70.7 53.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 2,627.1
bar=donor   line=cohort median 		509.6 582.1 94.6%
14 HBA1 protein_coding 10,329.5
bar=donor   line=cohort median 		1,931.5 1,960.7 94.0%
15 HBA2 protein_coding 7,467.9
bar=donor   line=cohort median 		1,068.0 1,083.5 96.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,014.5
bar=donor   line=cohort median 		7,011.1 6,938.4 52.6%
17 MT-CO2 protein_coding 7,691.2
bar=donor   line=cohort median 		5,968.9 5,810.8 75.4%
18 MT-ND1 protein_coding 5,923.3
bar=donor   line=cohort median 		3,670.4 3,718.2 87.3%
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