GSM6881371

Dataset: gse221521 • Sample: DM group RNA64 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,299,117 Total counts Group median: 12,709,871 • 73.3%ile (≈ Median)
22,267 Detected genes Group median: 2,638 • 2.3%ile (↓ Low)
3 Mitochondrial fraction (%) Group median: 6 • 2.3%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

40.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 11.19
bar=donor   line=cohort median 		12.92 31.4%
CETP Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.40 10.1%
SIRT6 Sirtuin Family 1.91
bar=donor   line=cohort median 		3.67 2.9%
SIRT1 Sirtuin Family 6.73
bar=donor   line=cohort median 		3.48 98.2%
SIRT3 Sirtuin Family 1.93
bar=donor   line=cohort median 		1.10 99.2%
IGF1R Insulin/IGF-1 Signaling 1.03
bar=donor   line=cohort median 		4.33 11.1%
KLOTHO Anti-aging 0.05
bar=donor   line=cohort median 		0.06 37.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 54.2%
IRS2 Insulin/IGF-1 Signaling 43.92
bar=donor   line=cohort median 		35.28 63.0%
TP53 Tumor Suppression 5.03
bar=donor   line=cohort median 		3.83 79.0%
SHC1 Signal Transduction 7.34
bar=donor   line=cohort median 		8.77 8.0%
ACE Signal Transduction 0.42
bar=donor   line=cohort median 		0.39 54.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 8,648.7 179,317
2 HBA1 ENSG00000206172 protein_coding 6,343.8 145,112
3 S100A9 ENSG00000163220 protein_coding 5,719.4 43,584
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,324.4 7,764
5 H3P6 ENSG00000235655 processed_pseudogene 4,029.5 22,025
6 FTL ENSG00000087086 protein_coding 3,661.7 42,415
7 DUSP1 ENSG00000120129 protein_coding 3,444.5 92,214
8 MT-CO1 ENSG00000198804 protein_coding 3,275.5 67,171
9 MT-ATP6 ENSG00000198899 protein_coding 3,045.4 27,581
10 RPS28P7 ENSG00000227097 processed_pseudogene 2,827.6 7,897

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,162.9
bar=donor   line=cohort median 		1,568.6 1,385.4 34.5%
2 S100A9 protein_coding 5,719.4
bar=donor   line=cohort median 		10,144.6 9,235.1 16.8%
3 IL1B protein_coding 12.2
bar=donor   line=cohort median 		6.9 6.1 84.2%
4 CXCL8 protein_coding 944.3
bar=donor   line=cohort median 		225.8 207.4 98.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.8
bar=donor   line=cohort median 		2.2 2.4 59.8%
6 FCGR3B protein_coding 119.4
bar=donor   line=cohort median 		157.0 129.3 42.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 642.8
bar=donor   line=cohort median 		802.6 706.2 42.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 27.0
bar=donor   line=cohort median 		56.8 56.4 4.9%
9 CD3E protein_coding 25.0
bar=donor   line=cohort median 		36.9 37.7 14.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.4
bar=donor   line=cohort median 		3.2 3.1 59.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 263.6
bar=donor   line=cohort median 		296.3 281.6 43.8%
12 GNLY protein_coding 65.4
bar=donor   line=cohort median 		77.5 70.7 41.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,325.7
bar=donor   line=cohort median 		509.6 582.1 81.6%
14 HBA1 protein_coding 6,343.8
bar=donor   line=cohort median 		1,931.5 1,960.7 85.8%
15 HBA2 protein_coding 2,523.2
bar=donor   line=cohort median 		1,068.0 1,083.5 78.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 3,275.5
bar=donor   line=cohort median 		7,011.1 6,938.4 1.8%
17 MT-CO2 protein_coding 1,928.4
bar=donor   line=cohort median 		5,968.9 5,810.8 1.3%
18 MT-ND1 protein_coding 1,439.8
bar=donor   line=cohort median 		3,670.4 3,718.2 2.8%
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