GSM6881372

Dataset: gse221521 • Sample: DM group RNA66 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,790,838 Total counts Group median: 12,709,871 • 82.1%ile (↑ High)
24,184 Detected genes Group median: 2,638 • 6.5%ile (↓ Low)
9 Mitochondrial fraction (%) Group median: 6 • 89.4%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

40.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 11.48
bar=donor   line=cohort median 		12.92 36.0%
CETP Lipid Metabolism 0.24
bar=donor   line=cohort median 		0.40 15.8%
SIRT6 Sirtuin Family 3.50
bar=donor   line=cohort median 		3.67 40.7%
SIRT1 Sirtuin Family 5.11
bar=donor   line=cohort median 		3.48 89.9%
SIRT3 Sirtuin Family 1.58
bar=donor   line=cohort median 		1.10 96.1%
IGF1R Insulin/IGF-1 Signaling 0.62
bar=donor   line=cohort median 		4.33 7.0%
KLOTHO Anti-aging 0.07
bar=donor   line=cohort median 		0.06 50.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 64.5%
IRS2 Insulin/IGF-1 Signaling 25.28
bar=donor   line=cohort median 		35.28 29.8%
TP53 Tumor Suppression 4.29
bar=donor   line=cohort median 		3.83 63.0%
SHC1 Signal Transduction 6.71
bar=donor   line=cohort median 		8.77 3.4%
ACE Signal Transduction 0.38
bar=donor   line=cohort median 		0.39 49.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 18,763.2 403,408
2 HBA1 ENSG00000206172 protein_coding 11,667.9 276,766
3 TMSB4XP8 ENSG00000187653 processed_pseudogene 9,811.7 18,267
4 MT-RNR1 ENSG00000211459 Mt_rRNA 8,836.6 116,259
5 MT-CO2 ENSG00000198712 protein_coding 8,295.3 78,249
6 MT-ATP6 ENSG00000198899 protein_coding 8,035.5 75,466
7 MT-CO1 ENSG00000198804 protein_coding 7,617.6 161,992
8 MT-ND1 ENSG00000198888 protein_coding 6,735.6 88,803
9 S100A9 ENSG00000163220 protein_coding 6,669.7 52,705
10 FTL ENSG00000087086 protein_coding 5,510.2 66,187

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,592.6
bar=donor   line=cohort median 		1,568.6 1,385.4 56.7%
2 S100A9 protein_coding 6,669.7
bar=donor   line=cohort median 		10,144.6 9,235.1 29.8%
3 IL1B protein_coding 5.6
bar=donor   line=cohort median 		6.9 6.1 46.4%
4 CXCL8 protein_coding 515.7
bar=donor   line=cohort median 		225.8 207.4 89.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 4.7
bar=donor   line=cohort median 		2.2 2.4 79.5%
6 FCGR3B protein_coding 194.8
bar=donor   line=cohort median 		157.0 129.3 74.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 811.6
bar=donor   line=cohort median 		802.6 706.2 60.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 73.7
bar=donor   line=cohort median 		56.8 56.4 70.2%
9 CD3E protein_coding 70.1
bar=donor   line=cohort median 		36.9 37.7 90.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.5
bar=donor   line=cohort median 		3.2 3.1 33.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 373.5
bar=donor   line=cohort median 		296.3 281.6 73.8%
12 GNLY protein_coding 102.5
bar=donor   line=cohort median 		77.5 70.7 70.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,960.3
bar=donor   line=cohort median 		509.6 582.1 91.5%
14 HBA1 protein_coding 11,667.9
bar=donor   line=cohort median 		1,931.5 1,960.7 96.1%
15 HBA2 protein_coding 4,456.6
bar=donor   line=cohort median 		1,068.0 1,083.5 89.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,617.6
bar=donor   line=cohort median 		7,011.1 6,938.4 60.9%
17 MT-CO2 protein_coding 8,295.3
bar=donor   line=cohort median 		5,968.9 5,810.8 83.7%
18 MT-ND1 protein_coding 6,735.6
bar=donor   line=cohort median 		3,670.4 3,718.2 93.5%
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