GSM6881373

Dataset: gse221521 • Sample: DM group RNA67 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,040,015 Total counts Group median: 12,709,871 • 28.8%ile (≈ Median)
27,315 Detected genes Group median: 2,638 • 72.8%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 52.6%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

47.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 16.23
bar=donor   line=cohort median 		12.92 74.9%
CETP Lipid Metabolism 0.24
bar=donor   line=cohort median 		0.40 14.8%
SIRT6 Sirtuin Family 3.44
bar=donor   line=cohort median 		3.67 36.0%
SIRT1 Sirtuin Family 4.47
bar=donor   line=cohort median 		3.48 81.6%
SIRT3 Sirtuin Family 0.80
bar=donor   line=cohort median 		1.10 9.6%
IGF1R Insulin/IGF-1 Signaling 8.06
bar=donor   line=cohort median 		4.33 96.1%
KLOTHO Anti-aging 0.10
bar=donor   line=cohort median 		0.06 71.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.08
bar=donor   line=cohort median 		0.07 59.3%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 70.97
bar=donor   line=cohort median 		35.28 90.4%
TP53 Tumor Suppression 3.54
bar=donor   line=cohort median 		3.83 39.1%
SHC1 Signal Transduction 7.34
bar=donor   line=cohort median 		8.77 8.6%
ACE Signal Transduction 0.45
bar=donor   line=cohort median 		0.39 60.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 8,207.7 152,381
2 MT-CO2 ENSG00000198712 protein_coding 7,052.0 58,076
3 S100A9 ENSG00000163220 protein_coding 7,002.1 48,307
4 MT-ATP6 ENSG00000198899 protein_coding 6,530.4 53,544
5 MT-RNR2 ENSG00000210082 Mt_rRNA 5,682.2 106,658
6 MT-CO3 ENSG00000198938 protein_coding 5,110.5 48,240
7 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,880.6 7,933
8 MT-ND4 ENSG00000198886 protein_coding 4,810.8 79,817
9 FTL ENSG00000087086 protein_coding 4,337.0 45,481
10 MT-ND1 ENSG00000198888 protein_coding 3,930.7 45,243

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,213.2
bar=donor   line=cohort median 		1,568.6 1,385.4 37.6%
2 S100A9 protein_coding 7,002.1
bar=donor   line=cohort median 		10,144.6 9,235.1 31.3%
3 IL1B protein_coding 5.8
bar=donor   line=cohort median 		6.9 6.1 48.4%
4 CXCL8 protein_coding 163.7
bar=donor   line=cohort median 		225.8 207.4 35.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.1
bar=donor   line=cohort median 		2.2 2.4 19.4%
6 FCGR3B protein_coding 94.4
bar=donor   line=cohort median 		157.0 129.3 31.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 573.1
bar=donor   line=cohort median 		802.6 706.2 35.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 44.2
bar=donor   line=cohort median 		56.8 56.4 30.8%
9 CD3E protein_coding 42.3
bar=donor   line=cohort median 		36.9 37.7 62.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.9
bar=donor   line=cohort median 		3.2 3.1 42.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 229.3
bar=donor   line=cohort median 		296.3 281.6 31.9%
12 GNLY protein_coding 91.5
bar=donor   line=cohort median 		77.5 70.7 64.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 31.2
bar=donor   line=cohort median 		509.6 582.1 0.3%
14 HBA1 protein_coding 178.1
bar=donor   line=cohort median 		1,931.5 1,960.7 0.3%
15 HBA2 protein_coding 68.4
bar=donor   line=cohort median 		1,068.0 1,083.5 0.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,207.7
bar=donor   line=cohort median 		7,011.1 6,938.4 70.7%
17 MT-CO2 protein_coding 7,052.0
bar=donor   line=cohort median 		5,968.9 5,810.8 70.7%
18 MT-ND1 protein_coding 3,930.7
bar=donor   line=cohort median 		3,670.4 3,718.2 57.3%
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