GSM6881375

Dataset: gse221521 • Sample: DM group RNA69 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,840,073 Total counts Group median: 12,709,871 • 58.8%ile (≈ Median)
26,609 Detected genes Group median: 2,638 • 54.7%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 52.1%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

55.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.25
bar=donor   line=cohort median 		0.17 74.4%
FOXO3 Insulin/IGF-1 Signaling 13.21
bar=donor   line=cohort median 		12.92 51.6%
CETP Lipid Metabolism 0.40
bar=donor   line=cohort median 		0.40 50.5%
SIRT6 Sirtuin Family 3.24
bar=donor   line=cohort median 		3.67 25.7%
SIRT1 Sirtuin Family 4.18
bar=donor   line=cohort median 		3.48 75.4%
SIRT3 Sirtuin Family 1.22
bar=donor   line=cohort median 		1.10 63.5%
IGF1R Insulin/IGF-1 Signaling 7.08
bar=donor   line=cohort median 		4.33 87.8%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 43.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.08
bar=donor   line=cohort median 		0.07 56.2%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 43.8%
IRS2 Insulin/IGF-1 Signaling 39.53
bar=donor   line=cohort median 		35.28 57.3%
TP53 Tumor Suppression 3.89
bar=donor   line=cohort median 		3.83 52.6%
SHC1 Signal Transduction 8.31
bar=donor   line=cohort median 		8.77 33.9%
ACE Signal Transduction 0.50
bar=donor   line=cohort median 		0.39 68.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 8,414.9 168,446
2 S100A9 ENSG00000163220 protein_coding 8,403.8 61,830
3 MT-CO1 ENSG00000198804 protein_coding 8,138.0 161,128
4 MT-CO2 ENSG00000198712 protein_coding 7,308.1 64,184
5 MT-CO3 ENSG00000198938 protein_coding 5,637.5 56,751
6 HBA1 ENSG00000206172 protein_coding 4,473.9 98,806
7 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,415.6 7,654
8 MT-ND4 ENSG00000198886 protein_coding 4,414.0 78,100
9 MT-RNR1 ENSG00000211459 Mt_rRNA 4,410.5 54,026
10 FTL ENSG00000087086 protein_coding 4,197.2 46,940

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,385.4
bar=donor   line=cohort median 		1,568.6 1,385.4 50.0%
2 S100A9 protein_coding 8,403.8
bar=donor   line=cohort median 		10,144.6 9,235.1 44.8%
3 IL1B protein_coding 9.5
bar=donor   line=cohort median 		6.9 6.1 74.9%
4 CXCL8 protein_coding 172.7
bar=donor   line=cohort median 		225.8 207.4 37.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 9.1
bar=donor   line=cohort median 		2.2 2.4 93.5%
6 FCGR3B protein_coding 104.3
bar=donor   line=cohort median 		157.0 129.3 36.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 969.3
bar=donor   line=cohort median 		802.6 706.2 71.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 56.4
bar=donor   line=cohort median 		56.8 56.4 50.5%
9 CD3E protein_coding 45.5
bar=donor   line=cohort median 		36.9 37.7 70.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.4
bar=donor   line=cohort median 		3.2 3.1 57.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 300.2
bar=donor   line=cohort median 		296.3 281.6 56.2%
12 GNLY protein_coding 70.0
bar=donor   line=cohort median 		77.5 70.7 48.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 642.1
bar=donor   line=cohort median 		509.6 582.1 55.7%
14 HBA1 protein_coding 4,473.9
bar=donor   line=cohort median 		1,931.5 1,960.7 75.4%
15 HBA2 protein_coding 1,755.3
bar=donor   line=cohort median 		1,068.0 1,083.5 67.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,138.0
bar=donor   line=cohort median 		7,011.1 6,938.4 70.2%
17 MT-CO2 protein_coding 7,308.1
bar=donor   line=cohort median 		5,968.9 5,810.8 72.3%
18 MT-ND1 protein_coding 3,384.6
bar=donor   line=cohort median 		3,670.4 3,718.2 36.5%
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