GSM6881376

Dataset: gse221521 • Sample: DM group RNA7 • Status: Diabetes mellitus without diabetic retinopathy
◂ Prev All Donors Next ▸

Quality Control Metrics

12,119,458 Total counts Group median: 12,709,871 • 31.9%ile (≈ Median)
25,890 Detected genes Group median: 2,638 • 30.8%ile (≈ Median)
8 Mitochondrial fraction (%) Group median: 6 • 83.2%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

39.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 19.79
bar=donor   line=cohort median 		12.92 94.6%
CETP Lipid Metabolism 0.23
bar=donor   line=cohort median 		0.40 13.7%
SIRT6 Sirtuin Family 2.20
bar=donor   line=cohort median 		3.67 4.9%
SIRT1 Sirtuin Family 3.41
bar=donor   line=cohort median 		3.48 42.8%
SIRT3 Sirtuin Family 0.53
bar=donor   line=cohort median 		1.10 0.3%
IGF1R Insulin/IGF-1 Signaling 7.40
bar=donor   line=cohort median 		4.33 92.5%
KLOTHO Anti-aging 0.11
bar=donor   line=cohort median 		0.06 78.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.08
bar=donor   line=cohort median 		0.07 58.8%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 114.62
bar=donor   line=cohort median 		35.28 98.7%
TP53 Tumor Suppression 2.61
bar=donor   line=cohort median 		3.83 14.3%
SHC1 Signal Transduction 7.85
bar=donor   line=cohort median 		8.77 16.3%
ACE Signal Transduction 0.13
bar=donor   line=cohort median 		0.39 4.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 11,672.1 220,535
2 MT-CO1 ENSG00000198804 protein_coding 8,680.5 162,223
3 S100A9 ENSG00000163220 protein_coding 8,418.8 58,464
4 MT-ATP6 ENSG00000198899 protein_coding 8,158.6 67,336
5 MT-CO2 ENSG00000198712 protein_coding 8,106.0 67,196
6 MT-CO3 ENSG00000198938 protein_coding 5,935.2 56,394
7 MT-RNR1 ENSG00000211459 Mt_rRNA 5,928.6 68,546
8 MT-ND1 ENSG00000198888 protein_coding 5,751.9 66,643
9 MT-ND4 ENSG00000198886 protein_coding 5,609.8 93,687
10 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,052.8 8,267

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,043.2
bar=donor   line=cohort median 		1,568.6 1,385.4 25.6%
2 S100A9 protein_coding 8,418.8
bar=donor   line=cohort median 		10,144.6 9,235.1 45.3%
3 IL1B protein_coding 5.6
bar=donor   line=cohort median 		6.9 6.1 46.9%
4 CXCL8 protein_coding 410.8
bar=donor   line=cohort median 		225.8 207.4 82.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.4
bar=donor   line=cohort median 		2.2 2.4 26.7%
6 FCGR3B protein_coding 199.1
bar=donor   line=cohort median 		157.0 129.3 75.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 870.9
bar=donor   line=cohort median 		802.6 706.2 65.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 35.2
bar=donor   line=cohort median 		56.8 56.4 14.8%
9 CD3E protein_coding 33.6
bar=donor   line=cohort median 		36.9 37.7 36.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.7
bar=donor   line=cohort median 		3.2 3.1 64.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 147.1
bar=donor   line=cohort median 		296.3 281.6 12.7%
12 GNLY protein_coding 53.7
bar=donor   line=cohort median 		77.5 70.7 30.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 311.7
bar=donor   line=cohort median 		509.6 582.1 26.7%
14 HBA1 protein_coding 1,480.0
bar=donor   line=cohort median 		1,931.5 1,960.7 37.6%
15 HBA2 protein_coding 786.9
bar=donor   line=cohort median 		1,068.0 1,083.5 37.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,680.5
bar=donor   line=cohort median 		7,011.1 6,938.4 80.1%
17 MT-CO2 protein_coding 8,106.0
bar=donor   line=cohort median 		5,968.9 5,810.8 80.6%
18 MT-ND1 protein_coding 5,751.9
bar=donor   line=cohort median 		3,670.4 3,718.2 86.8%
◂ Previous Donor Back to Donor List Next Donor ▸