GSM6881377

Dataset: gse221521 • Sample: DM group RNA72 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,092,302 Total counts Group median: 12,709,871 • 65.5%ile (≈ Median)
26,375 Detected genes Group median: 2,638 • 44.8%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 76.9%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

41.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.06
bar=donor   line=cohort median 		0.17 17.4%
FOXO3 Insulin/IGF-1 Signaling 14.51
bar=donor   line=cohort median 		12.92 61.4%
CETP Lipid Metabolism 0.41
bar=donor   line=cohort median 		0.40 54.7%
SIRT6 Sirtuin Family 2.65
bar=donor   line=cohort median 		3.67 8.6%
SIRT1 Sirtuin Family 4.03
bar=donor   line=cohort median 		3.48 71.2%
SIRT3 Sirtuin Family 1.10
bar=donor   line=cohort median 		1.10 51.0%
IGF1R Insulin/IGF-1 Signaling 4.70
bar=donor   line=cohort median 		4.33 54.2%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 12.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 40.81
bar=donor   line=cohort median 		35.28 58.8%
TP53 Tumor Suppression 4.15
bar=donor   line=cohort median 		3.83 59.8%
SHC1 Signal Transduction 8.21
bar=donor   line=cohort median 		8.77 29.8%
ACE Signal Transduction 0.49
bar=donor   line=cohort median 		0.39 66.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 10,941.8 223,331
2 MT-CO1 ENSG00000198804 protein_coding 8,497.9 171,558
3 MT-CO2 ENSG00000198712 protein_coding 7,957.9 71,264
4 S100A9 ENSG00000163220 protein_coding 6,651.7 49,900
5 MT-RNR1 ENSG00000211459 Mt_rRNA 6,312.0 78,837
6 MT-CO3 ENSG00000198938 protein_coding 6,258.4 64,238
7 MT-ND1 ENSG00000198888 protein_coding 5,087.7 63,679
8 HBA1 ENSG00000206172 protein_coding 4,701.5 105,873
9 MT-ND4 ENSG00000198886 protein_coding 4,646.6 83,830
10 FTL ENSG00000087086 protein_coding 4,472.8 51,005

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,005.0
bar=donor   line=cohort median 		1,568.6 1,385.4 22.0%
2 S100A9 protein_coding 6,651.7
bar=donor   line=cohort median 		10,144.6 9,235.1 28.8%
3 IL1B protein_coding 6.8
bar=donor   line=cohort median 		6.9 6.1 58.3%
4 CXCL8 protein_coding 213.3
bar=donor   line=cohort median 		225.8 207.4 51.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.9
bar=donor   line=cohort median 		2.2 2.4 13.7%
6 FCGR3B protein_coding 158.2
bar=donor   line=cohort median 		157.0 129.3 61.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 275.0
bar=donor   line=cohort median 		802.6 706.2 7.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 38.7
bar=donor   line=cohort median 		56.8 56.4 19.9%
9 CD3E protein_coding 59.0
bar=donor   line=cohort median 		36.9 37.7 86.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.3
bar=donor   line=cohort median 		3.2 3.1 53.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 389.8
bar=donor   line=cohort median 		296.3 281.6 75.9%
12 GNLY protein_coding 131.1
bar=donor   line=cohort median 		77.5 70.7 86.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 796.9
bar=donor   line=cohort median 		509.6 582.1 64.0%
14 HBA1 protein_coding 4,701.5
bar=donor   line=cohort median 		1,931.5 1,960.7 76.4%
15 HBA2 protein_coding 1,548.7
bar=donor   line=cohort median 		1,068.0 1,083.5 63.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,497.9
bar=donor   line=cohort median 		7,011.1 6,938.4 75.9%
17 MT-CO2 protein_coding 7,957.9
bar=donor   line=cohort median 		5,968.9 5,810.8 78.0%
18 MT-ND1 protein_coding 5,087.7
bar=donor   line=cohort median 		3,670.4 3,718.2 79.5%
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