GSM6881378

Dataset: gse221521 • Sample: DM group RNA74 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

14,013,027 Total counts Group median: 12,709,871 • 84.2%ile (↑ High)
25,250 Detected genes Group median: 2,638 • 15.8%ile (↓ Low)
13 Mitochondrial fraction (%) Group median: 6 • 97.7%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

50.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.25
bar=donor   line=cohort median 		0.17 73.8%
FOXO3 Insulin/IGF-1 Signaling 5.74
bar=donor   line=cohort median 		12.92 4.9%
CETP Lipid Metabolism 0.96
bar=donor   line=cohort median 		0.40 97.2%
SIRT6 Sirtuin Family 2.83
bar=donor   line=cohort median 		3.67 12.2%
SIRT1 Sirtuin Family 4.37
bar=donor   line=cohort median 		3.48 80.1%
SIRT3 Sirtuin Family 1.26
bar=donor   line=cohort median 		1.10 72.3%
IGF1R Insulin/IGF-1 Signaling 2.62
bar=donor   line=cohort median 		4.33 29.8%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 11.1%
APOC3 Lipid Metabolism 0.10
bar=donor   line=cohort median 		0.00 98.7%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 64.0%
IRS2 Insulin/IGF-1 Signaling 4.03
bar=donor   line=cohort median 		35.28 0.8%
TP53 Tumor Suppression 3.94
bar=donor   line=cohort median 		3.83 53.6%
SHC1 Signal Transduction 8.89
bar=donor   line=cohort median 		8.77 54.7%
ACE Signal Transduction 0.93
bar=donor   line=cohort median 		0.39 94.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 18,951.5 414,021
2 MT-RNR1 ENSG00000211459 Mt_rRNA 13,699.3 183,138
3 MT-CO1 ENSG00000198804 protein_coding 13,174.0 284,665
4 MT-CO2 ENSG00000198712 protein_coding 10,291.7 98,645
5 HBA1 ENSG00000206172 protein_coding 10,141.2 244,427
6 MT-ATP6 ENSG00000198899 protein_coding 9,893.9 94,416
7 MT-CO3 ENSG00000198938 protein_coding 9,215.3 101,241
8 MT-ND1 ENSG00000198888 protein_coding 8,710.1 116,685
9 MT-ND4 ENSG00000198886 protein_coding 7,859.2 151,761
10 MT-ATP8 ENSG00000228253 protein_coding 6,101.3 17,698

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 183.5
bar=donor   line=cohort median 		1,568.6 1,385.4 1.3%
2 S100A9 protein_coding 1,084.5
bar=donor   line=cohort median 		10,144.6 9,235.1 1.3%
3 IL1B protein_coding 0.8
bar=donor   line=cohort median 		6.9 6.1 4.9%
4 CXCL8 protein_coding 4.6
bar=donor   line=cohort median 		225.8 207.4 0.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.3
bar=donor   line=cohort median 		2.2 2.4 3.4%
6 FCGR3B protein_coding 10.5
bar=donor   line=cohort median 		157.0 129.3 1.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 186.2
bar=donor   line=cohort median 		802.6 706.2 2.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 92.2
bar=donor   line=cohort median 		56.8 56.4 85.8%
9 CD3E protein_coding 86.8
bar=donor   line=cohort median 		36.9 37.7 97.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.5
bar=donor   line=cohort median 		3.2 3.1 86.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 539.9
bar=donor   line=cohort median 		296.3 281.6 92.0%
12 GNLY protein_coding 98.7
bar=donor   line=cohort median 		77.5 70.7 69.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 3,064.1
bar=donor   line=cohort median 		509.6 582.1 95.6%
14 HBA1 protein_coding 10,141.2
bar=donor   line=cohort median 		1,931.5 1,960.7 93.0%
15 HBA2 protein_coding 3,172.8
bar=donor   line=cohort median 		1,068.0 1,083.5 82.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 13,174.0
bar=donor   line=cohort median 		7,011.1 6,938.4 98.2%
17 MT-CO2 protein_coding 10,291.7
bar=donor   line=cohort median 		5,968.9 5,810.8 93.0%
18 MT-ND1 protein_coding 8,710.1
bar=donor   line=cohort median 		3,670.4 3,718.2 96.6%
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