GSM6881379

Dataset: gse221521 • Sample: DM group RNA75 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

15,366,562 Total counts Group median: 12,709,871 • 93.0%ile (↑ High)
26,170 Detected genes Group median: 2,638 • 39.1%ile (≈ Median)
10 Mitochondrial fraction (%) Group median: 6 • 95.1%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

49.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.09
bar=donor   line=cohort median 		0.17 27.2%
FOXO3 Insulin/IGF-1 Signaling 6.81
bar=donor   line=cohort median 		12.92 7.0%
CETP Lipid Metabolism 1.21
bar=donor   line=cohort median 		0.40 98.2%
SIRT6 Sirtuin Family 3.57
bar=donor   line=cohort median 		3.67 44.3%
SIRT1 Sirtuin Family 5.12
bar=donor   line=cohort median 		3.48 90.4%
SIRT3 Sirtuin Family 1.08
bar=donor   line=cohort median 		1.10 45.3%
IGF1R Insulin/IGF-1 Signaling 3.74
bar=donor   line=cohort median 		4.33 43.8%
KLOTHO Anti-aging 0.03
bar=donor   line=cohort median 		0.06 23.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.07
bar=donor   line=cohort median 		0.07 50.0%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 38.6%
IRS2 Insulin/IGF-1 Signaling 7.97
bar=donor   line=cohort median 		35.28 5.4%
TP53 Tumor Suppression 5.92
bar=donor   line=cohort median 		3.83 92.5%
SHC1 Signal Transduction 9.65
bar=donor   line=cohort median 		8.77 80.6%
ACE Signal Transduction 0.34
bar=donor   line=cohort median 		0.39 42.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 18,418.1 441,233
2 MT-RNR1 ENSG00000211459 Mt_rRNA 12,502.9 183,289
3 MT-CO1 ENSG00000198804 protein_coding 10,495.9 248,704
4 MT-CO2 ENSG00000198712 protein_coding 9,053.5 95,159
5 MT-CO3 ENSG00000198938 protein_coding 8,831.5 106,396
6 TMSB4XP8 ENSG00000187653 processed_pseudogene 8,339.9 17,301
7 MT-ND1 ENSG00000198888 protein_coding 7,541.3 110,785
8 MT-ND4 ENSG00000198886 protein_coding 5,846.2 123,793
9 S100A9 ENSG00000163220 protein_coding 5,743.4 50,571
10 MT-ND3 ENSG00000198840 protein_coding 4,925.1 26,186

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 869.0
bar=donor   line=cohort median 		1,568.6 1,385.4 17.9%
2 S100A9 protein_coding 5,743.4
bar=donor   line=cohort median 		10,144.6 9,235.1 17.4%
3 IL1B protein_coding 5.7
bar=donor   line=cohort median 		6.9 6.1 47.4%
4 CXCL8 protein_coding 75.4
bar=donor   line=cohort median 		225.8 207.4 13.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.0
bar=donor   line=cohort median 		2.2 2.4 17.9%
6 FCGR3B protein_coding 101.8
bar=donor   line=cohort median 		157.0 129.3 35.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 648.6
bar=donor   line=cohort median 		802.6 706.2 43.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 111.2
bar=donor   line=cohort median 		56.8 56.4 90.4%
9 CD3E protein_coding 78.4
bar=donor   line=cohort median 		36.9 37.7 94.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.9
bar=donor   line=cohort median 		3.2 3.1 67.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 408.3
bar=donor   line=cohort median 		296.3 281.6 77.5%
12 GNLY protein_coding 88.8
bar=donor   line=cohort median 		77.5 70.7 63.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 831.5
bar=donor   line=cohort median 		509.6 582.1 66.1%
14 HBA1 protein_coding 2,897.5
bar=donor   line=cohort median 		1,931.5 1,960.7 64.5%
15 HBA2 protein_coding 2,469.9
bar=donor   line=cohort median 		1,068.0 1,083.5 76.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 10,495.9
bar=donor   line=cohort median 		7,011.1 6,938.4 94.0%
17 MT-CO2 protein_coding 9,053.5
bar=donor   line=cohort median 		5,968.9 5,810.8 86.3%
18 MT-ND1 protein_coding 7,541.3
bar=donor   line=cohort median 		3,670.4 3,718.2 95.6%
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