GSM6881380

Dataset: gse221521 • Sample: DR group RNA78 • Status: Diabetic retinopathy
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Quality Control Metrics

12,465,622 Total counts Group median: 12,498,211 • 43.8%ile (≈ Median)
24,840 Detected genes Group median: 27,368 • 11.7%ile (↓ Low)
4 Mitochondrial fraction (%) Group median: 6 • 7.0%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

35.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 18.24
bar=donor   line=cohort median 		12.92 86.8%
CETP Lipid Metabolism 0.32
bar=donor   line=cohort median 		0.40 32.4%
SIRT6 Sirtuin Family 3.08
bar=donor   line=cohort median 		3.67 20.5%
SIRT1 Sirtuin Family 2.87
bar=donor   line=cohort median 		3.48 22.0%
SIRT3 Sirtuin Family 0.68
bar=donor   line=cohort median 		1.10 3.9%
IGF1R Insulin/IGF-1 Signaling 5.56
bar=donor   line=cohort median 		4.33 72.3%
KLOTHO Anti-aging 0.19
bar=donor   line=cohort median 		0.06 94.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 85.52
bar=donor   line=cohort median 		35.28 95.6%
TP53 Tumor Suppression 2.29
bar=donor   line=cohort median 		3.83 4.9%
SHC1 Signal Transduction 7.48
bar=donor   line=cohort median 		8.77 9.6%
ACE Signal Transduction 0.15
bar=donor   line=cohort median 		0.39 7.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 25,724.8 183,747
2 MT-RNR2 ENSG00000210082 Mt_rRNA 6,630.9 128,864
3 FTL ENSG00000087086 protein_coding 6,039.0 65,569
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,745.5 7,986
5 MT-CO1 ENSG00000198804 protein_coding 4,294.9 82,557
6 MT-CO2 ENSG00000198712 protein_coding 3,571.6 30,453
7 H3P6 ENSG00000235655 processed_pseudogene 3,477.6 17,817
8 MT-CO3 ENSG00000198938 protein_coding 3,215.1 31,421
9 MT-RNR1 ENSG00000211459 Mt_rRNA 3,061.8 36,412
10 S100A8 ENSG00000143546 protein_coding 2,799.6 43,449

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,799.6
bar=donor   line=cohort median 		1,223.7 1,385.4 92.0%
2 S100A9 protein_coding 25,724.8
bar=donor   line=cohort median 		7,732.1 9,235.1 98.7%
3 IL1B protein_coding 6.5
bar=donor   line=cohort median 		4.9 6.1 55.2%
4 CXCL8 protein_coding 161.5
bar=donor   line=cohort median 		197.4 207.4 33.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.2
bar=donor   line=cohort median 		2.9 2.4 22.5%
6 FCGR3B protein_coding 148.6
bar=donor   line=cohort median 		108.9 129.3 57.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 2,082.7
bar=donor   line=cohort median 		581.4 706.2 98.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 15.5
bar=donor   line=cohort median 		51.6 56.4 0.8%
9 CD3E protein_coding 11.6
bar=donor   line=cohort median 		38.1 37.7 0.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 0.8
bar=donor   line=cohort median 		3.0 3.1 1.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 149.5
bar=donor   line=cohort median 		252.2 281.6 13.7%
12 GNLY protein_coding 45.0
bar=donor   line=cohort median 		58.9 70.7 21.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 408.2
bar=donor   line=cohort median 		585.0 582.1 35.0%
14 HBA1 protein_coding 973.8
bar=donor   line=cohort median 		1,960.4 1,960.7 26.2%
15 HBA2 protein_coding 833.8
bar=donor   line=cohort median 		1,080.5 1,083.5 40.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,294.9
bar=donor   line=cohort median 		6,740.9 6,938.4 7.0%
17 MT-CO2 protein_coding 3,571.6
bar=donor   line=cohort median 		5,693.7 5,810.8 6.5%
18 MT-ND1 protein_coding 2,365.8
bar=donor   line=cohort median 		3,876.8 3,718.2 11.1%
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