GSM6881382

Dataset: gse221521 • Sample: DR group RNA86 • Status: Diabetic retinopathy
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Quality Control Metrics

12,932,884 Total counts Group median: 12,498,211 • 61.9%ile (≈ Median)
27,368 Detected genes Group median: 27,368 • 74.4%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 61.4%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

59.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.08
bar=donor   line=cohort median 		0.17 23.6%
FOXO3 Insulin/IGF-1 Signaling 12.92
bar=donor   line=cohort median 		12.92 49.5%
CETP Lipid Metabolism 0.46
bar=donor   line=cohort median 		0.40 61.9%
SIRT6 Sirtuin Family 3.95
bar=donor   line=cohort median 		3.67 63.0%
SIRT1 Sirtuin Family 5.23
bar=donor   line=cohort median 		3.48 92.5%
SIRT3 Sirtuin Family 1.31
bar=donor   line=cohort median 		1.10 81.6%
IGF1R Insulin/IGF-1 Signaling 7.43
bar=donor   line=cohort median 		4.33 93.0%
KLOTHO Anti-aging 0.16
bar=donor   line=cohort median 		0.06 91.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 18.77
bar=donor   line=cohort median 		35.28 14.8%
TP53 Tumor Suppression 4.69
bar=donor   line=cohort median 		3.83 71.2%
SHC1 Signal Transduction 9.39
bar=donor   line=cohort median 		8.77 70.7%
ACE Signal Transduction 1.02
bar=donor   line=cohort median 		0.39 97.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 9,811.1 197,816
2 S100A9 ENSG00000163220 protein_coding 8,133.4 60,273
3 MT-CO1 ENSG00000198804 protein_coding 7,556.6 150,698
4 MT-CO3 ENSG00000198938 protein_coding 5,825.6 59,068
5 MT-RNR1 ENSG00000211459 Mt_rRNA 5,451.8 67,264
6 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,285.4 9,228
7 MT-CO2 ENSG00000198712 protein_coding 5,054.1 44,709
8 MT-ND3 ENSG00000198840 protein_coding 4,407.8 19,724
9 MT-ND4 ENSG00000198886 protein_coding 4,303.6 76,696
10 MT-ND1 ENSG00000198888 protein_coding 4,219.3 52,167

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,078.0
bar=donor   line=cohort median 		1,223.7 1,385.4 29.3%
2 S100A9 protein_coding 8,133.4
bar=donor   line=cohort median 		7,732.1 9,235.1 41.2%
3 IL1B protein_coding 6.9
bar=donor   line=cohort median 		4.9 6.1 59.3%
4 CXCL8 protein_coding 109.9
bar=donor   line=cohort median 		197.4 207.4 22.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.2
bar=donor   line=cohort median 		2.9 2.4 21.5%
6 FCGR3B protein_coding 133.5
bar=donor   line=cohort median 		108.9 129.3 51.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 950.5
bar=donor   line=cohort median 		581.4 706.2 70.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 83.4
bar=donor   line=cohort median 		51.6 56.4 79.5%
9 CD3E protein_coding 53.3
bar=donor   line=cohort median 		38.1 37.7 82.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.3
bar=donor   line=cohort median 		3.0 3.1 75.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 321.9
bar=donor   line=cohort median 		252.2 281.6 61.9%
12 GNLY protein_coding 99.3
bar=donor   line=cohort median 		58.9 70.7 69.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,194.7
bar=donor   line=cohort median 		585.0 582.1 77.5%
14 HBA1 protein_coding 1,957.1
bar=donor   line=cohort median 		1,960.4 1,960.7 49.0%
15 HBA2 protein_coding 1,572.6
bar=donor   line=cohort median 		1,080.5 1,083.5 63.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,556.6
bar=donor   line=cohort median 		6,740.9 6,938.4 60.4%
17 MT-CO2 protein_coding 5,054.1
bar=donor   line=cohort median 		5,693.7 5,810.8 28.8%
18 MT-ND1 protein_coding 4,219.3
bar=donor   line=cohort median 		3,876.8 3,718.2 66.1%
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