GSM6881383

Dataset: gse221521 • Sample: DM group RNA87 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,459,022 Total counts Group median: 12,709,871 • 15.8%ile (↓ Low)
26,138 Detected genes Group median: 2,638 • 38.1%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 63.5%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

47.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.09
bar=donor   line=cohort median 		0.17 29.8%
FOXO3 Insulin/IGF-1 Signaling 11.26
bar=donor   line=cohort median 		12.92 32.9%
CETP Lipid Metabolism 0.70
bar=donor   line=cohort median 		0.40 88.9%
SIRT6 Sirtuin Family 2.71
bar=donor   line=cohort median 		3.67 10.6%
SIRT1 Sirtuin Family 4.73
bar=donor   line=cohort median 		3.48 86.3%
SIRT3 Sirtuin Family 0.71
bar=donor   line=cohort median 		1.10 5.4%
IGF1R Insulin/IGF-1 Signaling 4.51
bar=donor   line=cohort median 		4.33 52.1%
KLOTHO Anti-aging 0.08
bar=donor   line=cohort median 		0.06 56.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.11
bar=donor   line=cohort median 		0.07 73.3%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 19.86
bar=donor   line=cohort median 		35.28 17.4%
TP53 Tumor Suppression 5.45
bar=donor   line=cohort median 		3.83 85.2%
SHC1 Signal Transduction 9.08
bar=donor   line=cohort median 		8.77 61.4%
ACE Signal Transduction 0.35
bar=donor   line=cohort median 		0.39 44.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 8,517.5 152,161
2 MT-CO1 ENSG00000198804 protein_coding 8,436.1 149,065
3 MT-CO2 ENSG00000198712 protein_coding 6,186.3 48,488
4 S100A9 ENSG00000163220 protein_coding 6,025.7 39,565
5 MT-CO3 ENSG00000198938 protein_coding 4,995.3 44,877
6 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,706.0 7,280
7 MT-ND4 ENSG00000198886 protein_coding 4,656.1 73,523
8 MT-RNR1 ENSG00000211459 Mt_rRNA 4,644.7 50,775
9 MT-ND1 ENSG00000198888 protein_coding 4,486.0 49,143
10 MT-ND3 ENSG00000198840 protein_coding 3,730.1 14,789

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 760.2
bar=donor   line=cohort median 		1,568.6 1,385.4 12.7%
2 S100A9 protein_coding 6,025.7
bar=donor   line=cohort median 		10,144.6 9,235.1 22.0%
3 IL1B protein_coding 24.1
bar=donor   line=cohort median 		6.9 6.1 97.7%
4 CXCL8 protein_coding 184.7
bar=donor   line=cohort median 		225.8 207.4 42.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.9
bar=donor   line=cohort median 		2.2 2.4 13.2%
6 FCGR3B protein_coding 182.2
bar=donor   line=cohort median 		157.0 129.3 70.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 702.4
bar=donor   line=cohort median 		802.6 706.2 49.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 35.5
bar=donor   line=cohort median 		56.8 56.4 15.8%
9 CD3E protein_coding 27.2
bar=donor   line=cohort median 		36.9 37.7 19.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 8.8
bar=donor   line=cohort median 		3.2 3.1 94.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 268.1
bar=donor   line=cohort median 		296.3 281.6 45.9%
12 GNLY protein_coding 111.4
bar=donor   line=cohort median 		77.5 70.7 76.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 308.7
bar=donor   line=cohort median 		509.6 582.1 25.6%
14 HBA1 protein_coding 818.9
bar=donor   line=cohort median 		1,931.5 1,960.7 20.5%
15 HBA2 protein_coding 679.0
bar=donor   line=cohort median 		1,068.0 1,083.5 31.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,436.1
bar=donor   line=cohort median 		7,011.1 6,938.4 74.9%
17 MT-CO2 protein_coding 6,186.3
bar=donor   line=cohort median 		5,968.9 5,810.8 58.8%
18 MT-ND1 protein_coding 4,486.0
bar=donor   line=cohort median 		3,670.4 3,718.2 71.8%
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