GSM6881384

Dataset: gse221521 • Sample: DM group RNA89 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,290,123 Total counts Group median: 12,709,871 • 72.8%ile (≈ Median)
24,880 Detected genes Group median: 2,638 • 12.2%ile (↓ Low)
6 Mitochondrial fraction (%) Group median: 6 • 50.0%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

37.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.16
bar=donor   line=cohort median 		0.17 48.5%
FOXO3 Insulin/IGF-1 Signaling 7.37
bar=donor   line=cohort median 		12.92 11.7%
CETP Lipid Metabolism 0.37
bar=donor   line=cohort median 		0.40 43.8%
SIRT6 Sirtuin Family 4.51
bar=donor   line=cohort median 		3.67 82.6%
SIRT1 Sirtuin Family 2.75
bar=donor   line=cohort median 		3.48 17.9%
SIRT3 Sirtuin Family 1.06
bar=donor   line=cohort median 		1.10 41.2%
IGF1R Insulin/IGF-1 Signaling 4.39
bar=donor   line=cohort median 		4.33 51.0%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 67.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 37.1%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 26.04
bar=donor   line=cohort median 		35.28 32.9%
TP53 Tumor Suppression 3.53
bar=donor   line=cohort median 		3.83 38.6%
SHC1 Signal Transduction 7.78
bar=donor   line=cohort median 		8.77 14.8%
ACE Signal Transduction 0.08
bar=donor   line=cohort median 		0.39 0.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 18,682.8 142,274
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,778.7 202,607
3 TMSB4XP8 ENSG00000187653 processed_pseudogene 8,332.0 14,949
4 MT-CO2 ENSG00000198712 protein_coding 7,356.1 66,870
5 FTL ENSG00000087086 protein_coding 7,207.4 83,431
6 MT-CO1 ENSG00000198804 protein_coding 7,007.7 143,611
7 MT-RNR1 ENSG00000211459 Mt_rRNA 6,753.3 85,624
8 MT-CO3 ENSG00000198938 protein_coding 6,350.1 66,165
9 MT-ND3 ENSG00000198840 protein_coding 3,909.4 17,977
10 MT-ND1 ENSG00000198888 protein_coding 3,315.8 42,129

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,607.2
bar=donor   line=cohort median 		1,568.6 1,385.4 89.4%
2 S100A9 protein_coding 18,682.8
bar=donor   line=cohort median 		10,144.6 9,235.1 92.0%
3 IL1B protein_coding 13.2
bar=donor   line=cohort median 		6.9 6.1 86.8%
4 CXCL8 protein_coding 301.0
bar=donor   line=cohort median 		225.8 207.4 66.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 10.7
bar=donor   line=cohort median 		2.2 2.4 96.1%
6 FCGR3B protein_coding 325.5
bar=donor   line=cohort median 		157.0 129.3 94.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 944.6
bar=donor   line=cohort median 		802.6 706.2 69.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 59.9
bar=donor   line=cohort median 		56.8 56.4 56.2%
9 CD3E protein_coding 31.7
bar=donor   line=cohort median 		36.9 37.7 30.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 0.8
bar=donor   line=cohort median 		3.2 3.1 1.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 447.4
bar=donor   line=cohort median 		296.3 281.6 84.2%
12 GNLY protein_coding 81.4
bar=donor   line=cohort median 		77.5 70.7 58.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 307.2
bar=donor   line=cohort median 		509.6 582.1 25.1%
14 HBA1 protein_coding 1,563.9
bar=donor   line=cohort median 		1,931.5 1,960.7 39.1%
15 HBA2 protein_coding 1,212.5
bar=donor   line=cohort median 		1,068.0 1,083.5 57.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,007.7
bar=donor   line=cohort median 		7,011.1 6,938.4 52.1%
17 MT-CO2 protein_coding 7,356.1
bar=donor   line=cohort median 		5,968.9 5,810.8 73.3%
18 MT-ND1 protein_coding 3,315.8
bar=donor   line=cohort median 		3,670.4 3,718.2 34.5%
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