GSM6881385

Dataset: gse221521 • Sample: Control group RNA90 • Status: Healthy control
◂ Prev All Donors Next ▸

Quality Control Metrics

13,065,127 Total counts Group median: 12,762,148 • 64.5%ile (≈ Median)
26,391 Detected genes Group median: 2,606 • 46.4%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 56.7%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

39.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.04
bar=donor   line=cohort median 		0.17 15.8%
FOXO3 Insulin/IGF-1 Signaling 15.51
bar=donor   line=cohort median 		12.92 69.2%
CETP Lipid Metabolism 0.23
bar=donor   line=cohort median 		0.40 14.3%
SIRT6 Sirtuin Family 2.09
bar=donor   line=cohort median 		3.67 3.9%
SIRT1 Sirtuin Family 5.18
bar=donor   line=cohort median 		3.48 92.0%
SIRT3 Sirtuin Family 0.77
bar=donor   line=cohort median 		1.10 8.6%
IGF1R Insulin/IGF-1 Signaling 5.55
bar=donor   line=cohort median 		4.33 71.8%
KLOTHO Anti-aging 0.21
bar=donor   line=cohort median 		0.06 96.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 36.89
bar=donor   line=cohort median 		35.28 53.6%
TP53 Tumor Suppression 2.77
bar=donor   line=cohort median 		3.83 16.8%
SHC1 Signal Transduction 7.63
bar=donor   line=cohort median 		8.77 12.7%
ACE Signal Transduction 0.46
bar=donor   line=cohort median 		0.39 62.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 10,126.9 75,813
2 MT-CO1 ENSG00000198804 protein_coding 8,460.9 170,456
3 MT-RNR2 ENSG00000210082 Mt_rRNA 7,350.7 149,722
4 MT-ATP6 ENSG00000198899 protein_coding 6,629.1 58,981
5 MT-CO2 ENSG00000198712 protein_coding 6,066.8 54,216
6 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,368.0 9,468
7 MT-ND4 ENSG00000198886 protein_coding 5,090.3 91,645
8 MT-CO3 ENSG00000198938 protein_coding 4,351.1 44,569
9 FTL ENSG00000087086 protein_coding 4,077.6 46,402
10 MT-ATP8 ENSG00000228253 protein_coding 3,688.0 9,974

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,630.7
bar=donor   line=cohort median 		1,535.8 1,385.4 58.3%
2 S100A9 protein_coding 10,126.9
bar=donor   line=cohort median 		10,851.3 9,235.1 58.3%
3 IL1B protein_coding 13.5
bar=donor   line=cohort median 		5.6 6.1 88.3%
4 CXCL8 protein_coding 245.8
bar=donor   line=cohort median 		220.4 207.4 56.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.5
bar=donor   line=cohort median 		1.7 2.4 54.7%
6 FCGR3B protein_coding 144.7
bar=donor   line=cohort median 		145.0 129.3 55.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 788.6
bar=donor   line=cohort median 		709.1 706.2 57.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 39.2
bar=donor   line=cohort median 		66.1 56.4 21.5%
9 CD3E protein_coding 36.0
bar=donor   line=cohort median 		37.6 37.7 44.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.1
bar=donor   line=cohort median 		3.1 3.1 73.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 166.6
bar=donor   line=cohort median 		302.3 281.6 16.8%
12 GNLY protein_coding 70.7
bar=donor   line=cohort median 		80.1 70.7 50.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 208.4
bar=donor   line=cohort median 		598.7 582.1 15.3%
14 HBA1 protein_coding 478.8
bar=donor   line=cohort median 		2,133.6 1,960.7 6.0%
15 HBA2 protein_coding 332.0
bar=donor   line=cohort median 		1,142.2 1,083.5 12.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,460.9
bar=donor   line=cohort median 		6,862.1 6,938.4 75.4%
17 MT-CO2 protein_coding 6,066.8
bar=donor   line=cohort median 		6,023.6 5,810.8 54.7%
18 MT-ND1 protein_coding 3,666.9
bar=donor   line=cohort median 		3,656.3 3,718.2 48.4%
◂ Previous Donor Back to Donor List Next Donor ▸