GSM6881386

Dataset: gse221521 • Sample: DR group RNA94 • Status: Diabetic retinopathy
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Quality Control Metrics

12,886,771 Total counts Group median: 12,498,211 • 60.4%ile (≈ Median)
15,493 Detected genes Group median: 27,368 • 0.8%ile (↓ Low)
2 Mitochondrial fraction (%) Group median: 6 • 0.3%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

31.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 0.65
bar=donor   line=cohort median 		12.92 0.8%
CETP Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.40 0.5%
SIRT6 Sirtuin Family 1.43
bar=donor   line=cohort median 		3.67 1.8%
SIRT1 Sirtuin Family 4.35
bar=donor   line=cohort median 		3.48 78.5%
SIRT3 Sirtuin Family 1.92
bar=donor   line=cohort median 		1.10 98.7%
IGF1R Insulin/IGF-1 Signaling 7.72
bar=donor   line=cohort median 		4.33 94.0%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 23.86
bar=donor   line=cohort median 		35.28 24.6%
TP53 Tumor Suppression 3.21
bar=donor   line=cohort median 		3.83 28.2%
SHC1 Signal Transduction 5.27
bar=donor   line=cohort median 		8.77 0.8%
ACE Signal Transduction 0.40
bar=donor   line=cohort median 		0.39 53.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 10,013.2 73,939
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,043.8 161,604
3 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,061.0 7,065
4 AC113935.1 ENSG00000226084 processed_pseudogene 3,339.4 23,884
5 RPS12 ENSG00000112306 protein_coding 3,145.6 30,646
6 RPL13AP5 ENSG00000236552 processed_pseudogene 2,980.0 23,502
7 RPS28P7 ENSG00000227097 processed_pseudogene 2,946.2 7,973
8 H3P6 ENSG00000235655 processed_pseudogene 2,894.6 15,331
9 RPS3AP6 ENSG00000234797 processed_pseudogene 2,868.7 29,390
10 RPL3P4 ENSG00000232573 processed_pseudogene 2,848.4 15,527

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,080.8
bar=donor   line=cohort median 		1,223.7 1,385.4 79.5%
2 S100A9 protein_coding 10,013.2
bar=donor   line=cohort median 		7,732.1 9,235.1 56.7%
3 IL1B protein_coding 13.3
bar=donor   line=cohort median 		4.9 6.1 87.8%
4 CXCL8 protein_coding 275.7
bar=donor   line=cohort median 		197.4 207.4 62.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.4
bar=donor   line=cohort median 		2.9 2.4 4.4%
6 FCGR3B protein_coding 1,035.8
bar=donor   line=cohort median 		108.9 129.3 99.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 983.7
bar=donor   line=cohort median 		581.4 706.2 71.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 59.9
bar=donor   line=cohort median 		51.6 56.4 56.7%
9 CD3E protein_coding 25.3
bar=donor   line=cohort median 		38.1 37.7 15.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 9.2
bar=donor   line=cohort median 		3.0 3.1 94.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 68.6
bar=donor   line=cohort median 		252.2 281.6 1.8%
12 GNLY protein_coding 44.3
bar=donor   line=cohort median 		58.9 70.7 19.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 472.3
bar=donor   line=cohort median 		585.0 582.1 42.2%
14 HBA1 protein_coding 1,780.5
bar=donor   line=cohort median 		1,960.4 1,960.7 45.9%
15 HBA2 protein_coding 791.3
bar=donor   line=cohort median 		1,080.5 1,083.5 38.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 1,894.9
bar=donor   line=cohort median 		6,740.9 6,938.4 0.8%
17 MT-CO2 protein_coding 403.4
bar=donor   line=cohort median 		5,693.7 5,810.8 0.3%
18 MT-ND1 protein_coding 54.1
bar=donor   line=cohort median 		3,876.8 3,718.2 0.3%
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