GSM6881388

Dataset: gse221521 • Sample: DM group RNA95 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,323,362 Total counts Group median: 12,709,871 • 38.1%ile (≈ Median)
27,015 Detected genes Group median: 2,638 • 67.1%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 57.3%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

47.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.09
bar=donor   line=cohort median 		0.17 26.2%
FOXO3 Insulin/IGF-1 Signaling 15.21
bar=donor   line=cohort median 		12.92 66.1%
CETP Lipid Metabolism 0.54
bar=donor   line=cohort median 		0.40 74.9%
SIRT6 Sirtuin Family 2.47
bar=donor   line=cohort median 		3.67 7.5%
SIRT1 Sirtuin Family 5.76
bar=donor   line=cohort median 		3.48 96.1%
SIRT3 Sirtuin Family 0.98
bar=donor   line=cohort median 		1.10 29.3%
IGF1R Insulin/IGF-1 Signaling 4.15
bar=donor   line=cohort median 		4.33 48.5%
KLOTHO Anti-aging 0.12
bar=donor   line=cohort median 		0.06 81.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.02
bar=donor   line=cohort median 		0.07 23.6%
TERT Telomere Maintenance 0.04
bar=donor   line=cohort median 		0.01 81.1%
IRS2 Insulin/IGF-1 Signaling 20.30
bar=donor   line=cohort median 		35.28 18.9%
TP53 Tumor Suppression 4.40
bar=donor   line=cohort median 		3.83 65.5%
SHC1 Signal Transduction 7.47
bar=donor   line=cohort median 		8.77 9.1%
ACE Signal Transduction 0.30
bar=donor   line=cohort median 		0.39 35.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 8,573.3 164,712
2 MT-CO1 ENSG00000198804 protein_coding 7,775.2 147,749
3 TMSB4XP8 ENSG00000187653 processed_pseudogene 6,353.5 10,570
4 MT-ATP6 ENSG00000198899 protein_coding 6,012.6 50,459
5 S100A9 ENSG00000163220 protein_coding 5,962.2 42,101
6 MT-CO2 ENSG00000198712 protein_coding 5,572.0 46,967
7 MT-ND4 ENSG00000198886 protein_coding 4,323.3 73,417
8 MT-ND1 ENSG00000198888 protein_coding 4,192.9 49,397
9 MT-RNR1 ENSG00000211459 Mt_rRNA 4,004.0 47,073
10 MT-CO3 ENSG00000198938 protein_coding 3,923.3 37,905

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,074.1
bar=donor   line=cohort median 		1,568.6 1,385.4 27.2%
2 S100A9 protein_coding 5,962.2
bar=donor   line=cohort median 		10,144.6 9,235.1 21.0%
3 IL1B protein_coding 16.1
bar=donor   line=cohort median 		6.9 6.1 92.0%
4 CXCL8 protein_coding 198.9
bar=donor   line=cohort median 		225.8 207.4 47.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.9
bar=donor   line=cohort median 		2.2 2.4 61.9%
6 FCGR3B protein_coding 189.9
bar=donor   line=cohort median 		157.0 129.3 73.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 940.1
bar=donor   line=cohort median 		802.6 706.2 69.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 30.3
bar=donor   line=cohort median 		56.8 56.4 7.5%
9 CD3E protein_coding 34.3
bar=donor   line=cohort median 		36.9 37.7 40.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.5
bar=donor   line=cohort median 		3.2 3.1 61.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 111.4
bar=donor   line=cohort median 		296.3 281.6 4.4%
12 GNLY protein_coding 19.0
bar=donor   line=cohort median 		77.5 70.7 1.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 395.7
bar=donor   line=cohort median 		509.6 582.1 33.9%
14 HBA1 protein_coding 873.2
bar=donor   line=cohort median 		1,931.5 1,960.7 22.0%
15 HBA2 protein_coding 474.1
bar=donor   line=cohort median 		1,068.0 1,083.5 21.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,775.2
bar=donor   line=cohort median 		7,011.1 6,938.4 62.4%
17 MT-CO2 protein_coding 5,572.0
bar=donor   line=cohort median 		5,968.9 5,810.8 41.7%
18 MT-ND1 protein_coding 4,192.9
bar=donor   line=cohort median 		3,670.4 3,718.2 64.0%
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