GSM6881389

Dataset: gse221521 • Sample: DM group RNA97 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

10,455,862 Total counts Group median: 12,709,871 • 6.5%ile (↓ Low)
24,781 Detected genes Group median: 2,638 • 11.1%ile (↓ Low)
5 Mitochondrial fraction (%) Group median: 6 • 22.0%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

48.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.15
bar=donor   line=cohort median 		0.17 46.4%
FOXO3 Insulin/IGF-1 Signaling 12.00
bar=donor   line=cohort median 		12.92 40.7%
CETP Lipid Metabolism 0.34
bar=donor   line=cohort median 		0.40 35.5%
SIRT6 Sirtuin Family 2.86
bar=donor   line=cohort median 		3.67 13.7%
SIRT1 Sirtuin Family 6.78
bar=donor   line=cohort median 		3.48 98.7%
SIRT3 Sirtuin Family 1.26
bar=donor   line=cohort median 		1.10 71.8%
IGF1R Insulin/IGF-1 Signaling 2.15
bar=donor   line=cohort median 		4.33 20.0%
KLOTHO Anti-aging 0.29
bar=donor   line=cohort median 		0.06 99.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 16.49
bar=donor   line=cohort median 		35.28 12.2%
TP53 Tumor Suppression 5.75
bar=donor   line=cohort median 		3.83 90.4%
SHC1 Signal Transduction 9.51
bar=donor   line=cohort median 		8.77 75.4%
ACE Signal Transduction 0.36
bar=donor   line=cohort median 		0.39 46.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 6,917.1 111,524
2 MT-ATP6 ENSG00000198899 protein_coding 5,915.6 42,122
3 MT-RNR2 ENSG00000210082 Mt_rRNA 5,106.7 83,243
4 S100A9 ENSG00000163220 protein_coding 4,735.4 28,371
5 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,478.1 6,321
6 MT-ND4 ENSG00000198886 protein_coding 4,340.9 62,544
7 MT-CO2 ENSG00000198712 protein_coding 4,329.3 30,962
8 FTL ENSG00000087086 protein_coding 4,229.6 38,519
9 MT-ND4L ENSG00000212907 protein_coding 3,446.3 10,702
10 MT-ATP8 ENSG00000228253 protein_coding 3,367.3 7,288

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 936.6
bar=donor   line=cohort median 		1,568.6 1,385.4 21.0%
2 S100A9 protein_coding 4,735.4
bar=donor   line=cohort median 		10,144.6 9,235.1 13.7%
3 IL1B protein_coding 15.2
bar=donor   line=cohort median 		6.9 6.1 90.9%
4 CXCL8 protein_coding 367.6
bar=donor   line=cohort median 		225.8 207.4 76.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.6
bar=donor   line=cohort median 		2.2 2.4 7.5%
6 FCGR3B protein_coding 264.8
bar=donor   line=cohort median 		157.0 129.3 90.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 877.4
bar=donor   line=cohort median 		802.6 706.2 66.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 34.2
bar=donor   line=cohort median 		56.8 56.4 12.7%
9 CD3E protein_coding 34.3
bar=donor   line=cohort median 		36.9 37.7 40.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 9.7
bar=donor   line=cohort median 		3.2 3.1 95.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 124.2
bar=donor   line=cohort median 		296.3 281.6 7.0%
12 GNLY protein_coding 60.6
bar=donor   line=cohort median 		77.5 70.7 37.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 51.8
bar=donor   line=cohort median 		509.6 582.1 1.3%
14 HBA1 protein_coding 450.7
bar=donor   line=cohort median 		1,931.5 1,960.7 5.4%
15 HBA2 protein_coding 178.6
bar=donor   line=cohort median 		1,068.0 1,083.5 3.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,917.1
bar=donor   line=cohort median 		7,011.1 6,938.4 49.0%
17 MT-CO2 protein_coding 4,329.3
bar=donor   line=cohort median 		5,968.9 5,810.8 14.2%
18 MT-ND1 protein_coding 2,426.0
bar=donor   line=cohort median 		3,670.4 3,718.2 12.7%
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