GSM6881390

Dataset: gse221521 • Sample: DR group RNA98 • Status: Diabetic retinopathy
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Quality Control Metrics

10,036,167 Total counts Group median: 12,498,211 • 3.4%ile (↓ Low)
25,337 Detected genes Group median: 27,368 • 16.8%ile (↓ Low)
5 Mitochondrial fraction (%) Group median: 6 • 26.7%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

50.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.03
bar=donor   line=cohort median 		0.17 13.7%
FOXO3 Insulin/IGF-1 Signaling 12.92
bar=donor   line=cohort median 		12.92 50.0%
CETP Lipid Metabolism 0.59
bar=donor   line=cohort median 		0.40 81.6%
SIRT6 Sirtuin Family 3.67
bar=donor   line=cohort median 		3.67 49.0%
SIRT1 Sirtuin Family 4.85
bar=donor   line=cohort median 		3.48 87.8%
SIRT3 Sirtuin Family 0.92
bar=donor   line=cohort median 		1.10 20.5%
IGF1R Insulin/IGF-1 Signaling 3.95
bar=donor   line=cohort median 		4.33 46.9%
KLOTHO Anti-aging 0.05
bar=donor   line=cohort median 		0.06 36.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.09
bar=donor   line=cohort median 		0.01 98.2%
IRS2 Insulin/IGF-1 Signaling 28.92
bar=donor   line=cohort median 		35.28 39.1%
TP53 Tumor Suppression 4.35
bar=donor   line=cohort median 		3.83 64.0%
SHC1 Signal Transduction 11.11
bar=donor   line=cohort median 		8.77 96.6%
ACE Signal Transduction 0.20
bar=donor   line=cohort median 		0.39 15.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 8,371.1 48,140
2 MT-CO1 ENSG00000198804 protein_coding 7,149.8 110,649
3 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,793.9 7,850
4 MT-CO3 ENSG00000198938 protein_coding 5,697.5 44,830
5 MT-RNR2 ENSG00000210082 Mt_rRNA 5,615.3 87,859
6 MT-CO2 ENSG00000198712 protein_coding 5,511.2 37,833
7 MT-ND4 ENSG00000198886 protein_coding 4,214.4 58,284
8 FTL ENSG00000087086 protein_coding 4,089.6 35,749
9 MT-ND1 ENSG00000198888 protein_coding 3,307.4 31,733
10 MT-ND4L ENSG00000212907 protein_coding 2,999.6 8,941

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,110.9
bar=donor   line=cohort median 		1,223.7 1,385.4 32.4%
2 S100A9 protein_coding 8,371.1
bar=donor   line=cohort median 		7,732.1 9,235.1 44.3%
3 IL1B protein_coding 10.4
bar=donor   line=cohort median 		4.9 6.1 79.0%
4 CXCL8 protein_coding 323.5
bar=donor   line=cohort median 		197.4 207.4 71.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.2
bar=donor   line=cohort median 		2.9 2.4 68.7%
6 FCGR3B protein_coding 219.3
bar=donor   line=cohort median 		108.9 129.3 83.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,594.0
bar=donor   line=cohort median 		581.4 706.2 93.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 31.8
bar=donor   line=cohort median 		51.6 56.4 10.1%
9 CD3E protein_coding 30.0
bar=donor   line=cohort median 		38.1 37.7 26.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.9
bar=donor   line=cohort median 		3.0 3.1 43.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 169.4
bar=donor   line=cohort median 		252.2 281.6 17.9%
12 GNLY protein_coding 54.4
bar=donor   line=cohort median 		58.9 70.7 31.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 390.1
bar=donor   line=cohort median 		585.0 582.1 32.4%
14 HBA1 protein_coding 2,343.1
bar=donor   line=cohort median 		1,960.4 1,960.7 58.8%
15 HBA2 protein_coding 1,002.9
bar=donor   line=cohort median 		1,080.5 1,083.5 44.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,149.8
bar=donor   line=cohort median 		6,740.9 6,938.4 53.6%
17 MT-CO2 protein_coding 5,511.2
bar=donor   line=cohort median 		5,693.7 5,810.8 40.2%
18 MT-ND1 protein_coding 3,307.4
bar=donor   line=cohort median 		3,876.8 3,718.2 33.9%
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