GSM6881391

Dataset: gse221521 • Sample: DR group R_JS001 • Status: Diabetic retinopathy
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Quality Control Metrics

10,746,227 Total counts Group median: 12,498,211 • 8.0%ile (↓ Low)
27,747 Detected genes Group median: 27,368 • 82.6%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 59.8%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

53.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.12
bar=donor   line=cohort median 		0.17 39.1%
FOXO3 Insulin/IGF-1 Signaling 14.33
bar=donor   line=cohort median 		12.92 59.8%
CETP Lipid Metabolism 0.40
bar=donor   line=cohort median 		0.40 49.0%
SIRT6 Sirtuin Family 2.27
bar=donor   line=cohort median 		3.67 5.4%
SIRT1 Sirtuin Family 4.62
bar=donor   line=cohort median 		3.48 83.2%
SIRT3 Sirtuin Family 1.25
bar=donor   line=cohort median 		1.10 67.6%
IGF1R Insulin/IGF-1 Signaling 4.78
bar=donor   line=cohort median 		4.33 57.3%
KLOTHO Anti-aging 0.08
bar=donor   line=cohort median 		0.06 60.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.07
bar=donor   line=cohort median 		0.07 53.6%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 44.90
bar=donor   line=cohort median 		35.28 64.0%
TP53 Tumor Suppression 5.85
bar=donor   line=cohort median 		3.83 90.9%
SHC1 Signal Transduction 10.74
bar=donor   line=cohort median 		8.77 93.5%
ACE Signal Transduction 0.21
bar=donor   line=cohort median 		0.39 16.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 8,644.0 143,237
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,257.9 121,595
3 MT-CO2 ENSG00000198712 protein_coding 6,042.0 44,411
4 MT-ATP6 ENSG00000198899 protein_coding 5,565.6 40,730
5 MT-ATP8 ENSG00000228253 protein_coding 5,171.1 11,503
6 S100A9 ENSG00000163220 protein_coding 4,980.2 30,666
7 MT-ND1 ENSG00000198888 protein_coding 4,446.8 45,684
8 MT-ND4 ENSG00000198886 protein_coding 4,415.3 65,383
9 MT-ND4L ENSG00000212907 protein_coding 4,333.8 13,832
10 MT-CO3 ENSG00000198938 protein_coding 4,049.4 34,116

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 879.1
bar=donor   line=cohort median 		1,223.7 1,385.4 18.4%
2 S100A9 protein_coding 4,980.2
bar=donor   line=cohort median 		7,732.1 9,235.1 15.3%
3 IL1B protein_coding 3.4
bar=donor   line=cohort median 		4.9 6.1 22.0%
4 CXCL8 protein_coding 78.5
bar=donor   line=cohort median 		197.4 207.4 14.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.9
bar=donor   line=cohort median 		2.9 2.4 61.4%
6 FCGR3B protein_coding 111.7
bar=donor   line=cohort median 		108.9 129.3 38.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 415.8
bar=donor   line=cohort median 		581.4 706.2 18.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 90.4
bar=donor   line=cohort median 		51.6 56.4 84.7%
9 CD3E protein_coding 37.1
bar=donor   line=cohort median 		38.1 37.7 48.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.1
bar=donor   line=cohort median 		3.0 3.1 50.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 299.0
bar=donor   line=cohort median 		252.2 281.6 55.7%
12 GNLY protein_coding 88.4
bar=donor   line=cohort median 		58.9 70.7 63.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 175.9
bar=donor   line=cohort median 		585.0 582.1 11.7%
14 HBA1 protein_coding 1,017.3
bar=donor   line=cohort median 		1,960.4 1,960.7 27.2%
15 HBA2 protein_coding 294.0
bar=donor   line=cohort median 		1,080.5 1,083.5 9.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,644.0
bar=donor   line=cohort median 		6,740.9 6,938.4 79.5%
17 MT-CO2 protein_coding 6,042.0
bar=donor   line=cohort median 		5,693.7 5,810.8 53.6%
18 MT-ND1 protein_coding 4,446.8
bar=donor   line=cohort median 		3,876.8 3,718.2 70.2%
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